Property Summary

NCBI Gene PubMed Count 39
PubMed Score 28.57
PubTator Score 34.45

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Endometriosis 535
Disease Target Count P-value
psoriasis 6685 2.12735289533564E-21
breast carcinoma 1614 8.09581406796888E-12
non-small cell lung cancer 2798 1.81125860438396E-11
cystic fibrosis 1670 1.44066306855595E-6
lung carcinoma 2844 1.31549217394592E-5
Breast cancer 3099 1.66753353074902E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00311953823054365
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00312536917033259
primary pancreatic ductal adenocarcinoma 1271 0.00944279289126255
pituitary cancer 1972 0.0185869811933458
invasive ductal carcinoma 2950 0.0194886404163688
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0379848064328289
Disease Target Count Z-score Confidence
Neuritis 6 3.215 1.6



Accession Q96QR1 Q96PL0
Symbols HIN1


  Ortholog (5)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid

Gene RIF (27)

26370119 Tumor-adjacent tissues showed higher methylation status of RASSF1A, HIN-1 and MGMT promoters.
24850174 aberrant HIN-1 promoter methylation could be an independent and important biomarker used in predicting the prognosis and progression of breast cancer
24710847 SCGB3A1-183 T and SCGB3A1 IVS1-189 A alleles might have a protective effect against nasal polyposis.
22871047 Methylation of HIN-1 promoter is a novel epigenetic biomarker associated with poor outcomes in OCCA patients.
22695491 Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancers was associated with clinical characteristics, but only RASSF1A methylation was associated with time to first recurrence and overall survival.
22095135 analysis of AKT signaling pathway activated by HIN-1 methylation in non-small cell lung cancer
22048254 HIN1, was the most "dietary sensitive" genes, as methylation of their promoters was associated with intakes of at least two out of the eight dietary methyl factors examined.
21812955 Data show that SCGB3A1 was down-regulated in invasive compared with DCIS, whereas talin 2 (TLN2) and PTGS1 were up-regulated in invasive compared with DCIS.
21274384 Data suggest that high methylation of the HIN-1 promoter results in silenced HIN-1 expression in gastric cancer, and that 5-aza-2'-deoxycytidine reverses HIN-1 methylation and reduces viability of gastric cancer cells.
20642860 Hypermethylation of HIN-1 is associated with lymphatic metastasis of breast cancers.

AA Sequence

LIEGSQKCVAELGPQAVGAVKALKALLGALTVFG                                         71 - 104

Text Mined References (40)

PMID Year Title
26370119 2015 Applicability of HIN-1, MGMT and RASSF1A promoter methylation as biomarkers for detecting field cancerization in breast cancer.
24850174 2014 Aberrant promoter methylation of HIN-1 gene may contribute to the pathogenesis of breast cancer: a meta-analysis.
24710847 2014 Investigation of SCGB3A1 (UGRP2) gene arrays in patients with nasal polyposis.
22871047 2012 Promoter methylation status of HIN-1 associated with outcomes of ovarian clear cell adenocarcinoma.
22695491 2012 Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome.
22155607 2011 Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily.
22095135 2012 AKT signaling pathway activated by HIN-1 methylation in non-small cell lung cancer.
22048254 2011 The influence of one-carbon metabolism on gene promoter methylation in a population-based breast cancer study.
21812955 2011 Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas.
21274384 2011 Silence of HIN-1 expression through methylation of its gene promoter in gastric cancer.