Tdark HS3ST6 Heparan sulfate glucosamine 3-O-sulfotransferase 6

Protein Summary

Description

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Uniprot Accession IDs

• Q96QI5
• Q96RX7

Gene Name

• HS3ST6

Ensembl ID

• ENST00000293937
• ENSP00000293937
• ENSG00000276333
• ENST00000454677
• ENSP00000416741
• ENSG00000162040

Symbol

• HS3ST5
• HS3ST5
• 3-OST-6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.65
cellular component	0.61
cell type or tissue	0.52
cell line	0.5
PubMedID	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.81   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 26   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.81   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0