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Tchem
CDK15
Cyclin-dependent kinase 15

Protein Summary
Description
Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260967
  • ENSP00000260967
  • ENSG00000138395
  • ENST00000410091
  • ENSP00000386901
  • ENST00000434439
  • ENSP00000412775
  • ENST00000450471
  • ENSP00000406472

Symbol
  • ALS2CR7
  • PFTK2
  • PFTK2
  • ALS2CR7
  • PFTAIRE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
cellular component
0.75
protein domain
0.73
cell type or tissue
0.72
tissue
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.11   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.11   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0