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Tbio Perilipin-4

May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity).

Members of the perilipin family, such as PLIN4, coat intracellular lipid storage droplets (Wolins et al., 2003 [PubMed 12840023]).[supplied by OMIM, Feb 2010]

 Comments

Property Summary

NCBI Gene PubMed Count 10
PubMed Score 14.52
PubTator Score 12.75

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count P-value
invasive ductal carcinoma 2951 2.1e-04
ductal carcinoma in situ 1745 2.4e-04
breast carcinoma 1638 5.3e-04
psoriasis 6694 4.4e-03
fibroadenoma 559 7.8e-03
Atopic dermatitis 952 8.7e-03
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.9
Disease Target Count Z-score Confidence
Obesity 678 3.222 1.6

Expression

  Differential Expression (6)

Disease log2 FC p
Atopic dermatitis -1.700 8.7e-03
breast carcinoma -3.200 5.3e-04
ductal carcinoma in situ -4.400 2.4e-04
fibroadenoma -4.000 7.8e-03
invasive ductal carcinoma -5.100 2.1e-04
psoriasis -1.100 4.4e-03

Synonym

Accession Q96Q06 A6NEI2
Symbols S3-12
KIAA1881

Gene

PLIN4

  Ortholog (7)

Species Source Disease
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
OMA EggNOG

 UniProt Keyword (10)

 GO Component (4)

 Compartment GO Term (20)

See all...

 IMPC Phenotype (2)

 MGI Phenotype (2)

 GWAS Trait (8)

 HCA RNA Cell Line (56)

See all...

Pathway (1)

Gene RIF (6)

AA Sequence 

MQTLGSFFGSLPGFSSARNLVANAHSSARARPAADPTGAPAAEAAQPQAQVAAHPEQTAPWTEKELQPSE      1 - 70
KQMVSGAKDLVCSKMSRAKDAVSSGVASVVDVAKGVVQGGLDTTRSALTGTKEVVSSGVTGAMDMAKGAV     71 - 140
QGGLDTSKAVLTGTKDTVSTGLTGAVNVAKGTVQAGVDTTKTVLTGTKDTVTTGVMGAVNLAKGTVQTGV    141 - 210
ETSKAVLTGTKDAVSTGLTGAVNVARGSIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSK    211 - 280
TVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTTKTVLT    281 - 350
GTKNTVCSGVTGAVNLAKEAIQGGLDTTKSMVMGTKDTMSTGLTGAANVAKGAMQTGLNTTQNIATGTKD    351 - 420
TVCSGVTGAMNLARGTIQTGVDTTKIVLTGTKDTVCSGVTGAANVAKGAVQGGLDTTKSVLTGTKDAVST    421 - 490
GLTGAVNVAKGTVQTGVDTTKTVLTGTKDTVCSGVTSAVNVAKGAVQGGLDTTKSVVIGTKDTMSTGLTG    491 - 560
AANVAKGAVQTGVDTAKTVLTGTKDTVTTGLVGAVNVAKGTVQTGMDTTKTVLTGTKDTIYSGVTSAVNV    561 - 630
AKGAVQTGLKTTQNIATGTKNTFGSGVTSAVNVAKGAAQTGVDTAKTVLTGTKDTVTTGLMGAVNVAKGT    631 - 700
VQTSVDTTKTVLTGTKDTVCSGVTGAANVAKGAIQGGLDTTKSVLTGTKDAVSTGLTGAVKLAKGTVQTG    701 - 770
MDTTKTVLTGTKDAVCSGVTGAANVAKGAVQMGVDTAKTVLTGTKDTVCSGVTGAANVAKGAVQTGLKTT    771 - 840
QNIATGTKNTLGSGVTGAAKVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNLAKGTVQTGVDTSKTVL    841 - 910
TGTKDTVCSGVTGAVNVAKGTVQTGVDTAKTVLSGAKDAVTTGVTGAVNVAKGTVQTGVDASKAVLMGTK    911 - 980
DTVFSGVTGAMSMAKGAVQGGLDTTKTVLTGTKDAVSAGLMGSGNVATGATHTGLSTFQNWLPSTPATSW    981 - 1050
GGLTSSRTTDNGGEQTALSPQEAPFSGISTPPDVLSVGPEPAWEAAATTKGLATDVATFTQGAAPGREDT   1051 - 1120
GLLATTHGPEEAPRLAMLQNELEGLGDIFHPMNAEEQAQLAASQPGPKVLSAEQGSYFVRLGDLGPSFRQ   1121 - 1190
RAFEHAVSHLQHGQFQARDTLAQLQDCFRLIEKAQQAPEGQPRLDQGSGASAEDAAVQEERDAGVLSRVC   1191 - 1260
GLLRQLHTAYSGLVSSLQGLPAELQQPVGRARHSLCELYGIVASAGSVEELPAERLVQSREGVHQAWQGL   1261 - 1330
EQLLEGLQHNPPLSWLVGPFALPAGGQ                                              1331 - 1357
//

Text Mined References (13)

PMID Year Title