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Tbio Perilipin-4

May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity).

Members of the perilipin family, such as PLIN4, coat intracellular lipid storage droplets (Wolins et al., 2003 [PubMed 12840023]).[supplied by OMIM, Feb 2010]

 Comments

Property Summary

NCBI Gene PubMed Count 9
PubMed Score 13.05
PubTator Score 12.75

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
psoriasis 6685 5.3085463306618E-13
invasive ductal carcinoma 2950 2.11365915484708E-4
ductal carcinoma in situ 1745 2.44259525123837E-4
breast carcinoma 1614 5.34406880875253E-4
fibroadenoma 557 0.00777352086314217
Atopic dermatitis 944 0.00865094933233799
Disease Target Count Z-score Confidence
Obesity 616 3.11 1.6

Expression

  Differential Expression (6)

Disease log2 FC p
Atopic dermatitis -1.700 0.009
breast carcinoma -3.200 0.001
fibroadenoma -4.000 0.008
psoriasis -1.400 0.000
ductal carcinoma in situ -4.400 0.000
invasive ductal carcinoma -5.100 0.000

Synonym

Accession Q96Q06 A6NEI2
Symbols S3-12
KIAA1881

Gene

PLIN4

PANTHER Protein Class (1)

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG
Pig OMA EggNOG
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG

 GO Component (4)

 Compartment GO Term (19)

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 IMPC Term (1)

 MGI Term (3)

 HCA RNA Cell Line (56)

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Pathway (2)

 UniProt Keyword (10)

Gene RIF (6)

PMID Text
22667335 PLIN2-PLIN5 proteins were all more abundant in women than in men (p = 0.037 and p < 0.0001, respectively), consistent with higher intramyocellular lipid content observed in female skeletal muscle.
22210160 we found a significant association between one single-nucleotide polymorphism in PLIN4 and height but not with bone traits
21533135 These results suggest variation at the PLIN4 locus, and its interaction with PUFA as a modulator of obesity related phenotypes, acts in part through creation of a miR-522 regulatory site
20495294 Those findings indicate improvement and conservation of lifestyle depending on genetic predisposition in ADIPOQ, PLIN and LIPE should be encouraged.
20495294 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
12840023 Characterization of homologous mouse gene product, plasma membrane associated protein, S3-12.

AA Sequence 

MQTLGSFFGSLPGFSSARNLVANAHSSARARPAADPTGAPAAEAAQPQAQVAAHPEQTAPWTEKELQPSE      1 - 70
KQMVSGAKDLVCSKMSRAKDAVSSGVASVVDVAKGVVQGGLDTTRSALTGTKEVVSSGVTGAMDMAKGAV     71 - 140
QGGLDTSKAVLTGTKDTVSTGLTGAVNVAKGTVQAGVDTTKTVLTGTKDTVTTGVMGAVNLAKGTVQTGV    141 - 210
ETSKAVLTGTKDAVSTGLTGAVNVARGSIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSK    211 - 280
TVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTTKTVLT    281 - 350
GTKNTVCSGVTGAVNLAKEAIQGGLDTTKSMVMGTKDTMSTGLTGAANVAKGAMQTGLNTTQNIATGTKD    351 - 420
TVCSGVTGAMNLARGTIQTGVDTTKIVLTGTKDTVCSGVTGAANVAKGAVQGGLDTTKSVLTGTKDAVST    421 - 490
GLTGAVNVAKGTVQTGVDTTKTVLTGTKDTVCSGVTSAVNVAKGAVQGGLDTTKSVVIGTKDTMSTGLTG    491 - 560
AANVAKGAVQTGVDTAKTVLTGTKDTVTTGLVGAVNVAKGTVQTGMDTTKTVLTGTKDTIYSGVTSAVNV    561 - 630
AKGAVQTGLKTTQNIATGTKNTFGSGVTSAVNVAKGAAQTGVDTAKTVLTGTKDTVTTGLMGAVNVAKGT    631 - 700
VQTSVDTTKTVLTGTKDTVCSGVTGAANVAKGAIQGGLDTTKSVLTGTKDAVSTGLTGAVKLAKGTVQTG    701 - 770
MDTTKTVLTGTKDAVCSGVTGAANVAKGAVQMGVDTAKTVLTGTKDTVCSGVTGAANVAKGAVQTGLKTT    771 - 840
QNIATGTKNTLGSGVTGAAKVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNLAKGTVQTGVDTSKTVL    841 - 910
TGTKDTVCSGVTGAVNVAKGTVQTGVDTAKTVLSGAKDAVTTGVTGAVNVAKGTVQTGVDASKAVLMGTK    911 - 980
DTVFSGVTGAMSMAKGAVQGGLDTTKTVLTGTKDAVSAGLMGSGNVATGATHTGLSTFQNWLPSTPATSW    981 - 1050
GGLTSSRTTDNGGEQTALSPQEAPFSGISTPPDVLSVGPEPAWEAAATTKGLATDVATFTQGAAPGREDT   1051 - 1120
GLLATTHGPEEAPRLAMLQNELEGLGDIFHPMNAEEQAQLAASQPGPKVLSAEQGSYFVRLGDLGPSFRQ   1121 - 1190
RAFEHAVSHLQHGQFQARDTLAQLQDCFRLIEKAQQAPEGQPRLDQGSGASAEDAAVQEERDAGVLSRVC   1191 - 1260
GLLRQLHTAYSGLVSSLQGLPAELQQPVGRARHSLCELYGIVASAGSVEELPAERLVQSREGVHQAWQGL   1261 - 1330
EQLLEGLQHNPPLSWLVGPFALPAGGQ                                              1331 - 1357
//

Text Mined References (12)

PMID Year Title
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
22667335 2012 Perilipin family (PLIN) proteins in human skeletal muscle: the effect of sex, obesity, and endurance training.
22210160 2012 A Polymorphism in a gene encoding Perilipin 4 is associated with height but not with bone measures in individuals from the Framingham Osteoporosis Study.
21533135 2011 The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site.
21498505 2011 Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine.
20495294 2010 Association of lifestyle factors, polymorphisms in adiponectin, perilipin and hormone sensitive lipase, and clinical markers in Japanese males.
19638644 2010 Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins.
15111493 2004 Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma.
15057824 2004 The DNA sequence and biology of human chromosome 19.
12840023 2003 Adipocyte protein S3-12 coats nascent lipid droplets.
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