Tchem LMTK3 Serine/threonine-protein kinase LMTK3

Protein Summary

Description

Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).

Uniprot Accession IDs

• Q96Q04
• Q4G0U1

Gene Name

• LMTK3

Ensembl ID

• ENST00000600059
• ENSP00000472020
• ENSG00000142235

Symbol

• KIAA1883
• TYKLM3
• LMR3
• TYKLM3
• PPP1R101

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
protein domain	0.73
tissue sample	0.65
histone modification site profile	0.61
cell type or tissue	0.54

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Lmr Family / Serine/threonine-protein Kinase Lmtk3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.78   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.78   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0