Property Summary

NCBI Gene PubMed Count 14
PubMed Score 5.14
PubTator Score 168.92

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (4)

Disease Target Count P-value
ulcerative colitis 2087 1.02433105065436E-7
pituitary cancer 1972 3.27516404427283E-6
interstitial cystitis 2299 1.37239621532217E-4
medulloblastoma, large-cell 6234 2.03895505660397E-4
glioblastoma 5572 8.79750718736479E-4
ovarian cancer 8492 9.47720535070878E-4
primary Sjogren syndrome 789 0.00157376519240701
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00665991214246538
sarcoidosis 368 0.00708361781905726
head and neck cancer 270 0.00861325597964981
chronic rhinosinusitis 512 0.0104976854177538
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.019953765888582
osteosarcoma 7933 0.0446064353109104
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Swayback 2 5.656 2.8

Expression

  Differential Expression (13)

Disease log2 FC p
osteosarcoma -1.587 0.045
glioblastoma -1.200 0.001
medulloblastoma, large-cell -1.600 0.000
intraductal papillary-mucinous adenoma (... 1.100 0.007
intraductal papillary-mucinous neoplasm ... 1.700 0.020
sarcoidosis 1.400 0.007
interstitial cystitis -1.200 0.000
primary Sjogren syndrome 1.400 0.002
ulcerative colitis 1.300 0.000
ovarian cancer -1.400 0.001
pituitary cancer 1.700 0.000
chronic rhinosinusitis -1.035 0.010
head and neck cancer -1.200 0.009

Synonym

Accession Q96PN7 Q05GC6 Q7Z6T2 Q7Z6T3 Q9NQ72 Q9NQ73 Q9NUN9
Symbols RAPA
BCAR2
TREP132
TReP-132
HSA277276
dJ139D8.5

Gene

  Ortholog (12)

Species Source
Chimp OMA EggNOG Inparanoid
Macaque OMA EggNOG
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

Gene RIF (8)

PMID Text
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
17015480 identify TReP-132 as a coactivator of progesterone receptor mediating the growth-inhibitory and differentiation effects of progesterone on breast cancer cells
15899840 TReP-132 is a basal cell cycle regulatory protein interacting with Sp1 to activate the p21 and p27 gene promoters.
15072559 TReP-132 is a trans-acting factor of genes involved in adrenal glucocorticoid, C(19) steroid and estrogen production.
12530663 TReP-132 interacts with steroidogenic factor-1 (SF-1) through specific domains; and along with the interaction with CBP/p300 these factors are postulated to form a complex to regulate expression of the P450scc gene.
12101186 TReP-132 plays a role in regulating p450scc expression with steroidogenic factor-1 and CBP/p300

AA Sequence

MGDQQLYKTNHVAHGSENLFYQQPPLGVHSGLNHNYGNAVTGGGMDAPQASPISPHFPQDTRDGLGLPVG      1 - 70
SKNLGQMDTSRQGGWGSHAGPGNHVQLRGNLANSNMMWGAPAQAEPTDGYQYTYSQASEIRTQKLTSGVL     71 - 140
HKLDSFTQVFANQNLRIQVNNMAQVLHTQSAVMDGAPDSALRQLLSQKPMEPPAPAIPSRYQQVPQQPHP    141 - 210
GFTGGLSKPALQVGQHPTQGHLYYDYQQPLAQVPVQGGQPLQAPQMLSQHMQQMQQHQYYPPQQQQQAGQ    211 - 280
QRISMQEIQTQPQQIRPSQPQPPPQQQQPQQLQLQQRQGSMQIPQYYQPQPMMQHLQEQQQQQMHLQPPS    281 - 350
YHRDPHQYTPEQAHTVQLIPLGSMSQYYYQEPQQPYSHPLYQQSHLSQHQQREDSQLKTYSSDRQAQAML    351 - 420
SSHGDLGPPDTGMGDPASSDLTRVSSTLPHRPLLSPSGIHLNNMGPQHQQLSPSAMWPQMHLPDGRAQPG    421 - 490
SPESSGQPKGAFGEQFDAKNKLTCSICLKEFKNLPALNGHMRSHGGMRASPNLKQEEGEKVLPPQPQPPL    491 - 560
PPPPPPPPPPQLPPEAESLTPMVMPVSVPVKLLPPKPSSQGFTNSTVAAPSARDKPASSMSDDEMPVLEI    561 - 630
PRKHQPSVPKAEEPLKTVQEKKKFRHRPEPLFIPPPPSYNPNPAASYSGATLYQSQLRSPRVLGDHLLLD    631 - 700
PTHELPPYTPPPMLSPVRQGSGLFSNVLISGHGPGAHPQLPLTPLTPTPRVLLCRSNSIDGSNVTVTPGP    701 - 770
GEQTVDVEPRINIGLRFQAEIPELQDISALAQDTHKATLVWKPWPELENHDLQQRVENLLNLCCSSALPG    771 - 840
GGTNSEFALHSLFEAKGDVMVALEMLLLRKPVRLKCHPLANYHYAGSDKWTSLERKLFNKALATYSKDFI    841 - 910
FVQKMVKSKTVAQCVEYYYTWKKIMRLGRKHRTRLAEIIDDCVTSEEEEELEEEEEEDPEEDRKSTKEEE    911 - 980
SEVPKSPEPPPVPVLAPTEGPPLQALGQPSGSFICEMPNCGAVFSSRQALNGHARIHGGTNQVTKARGAI    981 - 1050
PSGKQKPGGTQSGYCSVKSSPSHSTTSGETDPTTIFPCKECGKVFFKIKSRNAHMKTHRQQEEQQRQKAQ   1051 - 1120
KAAFAAEMAATIERTTGPVGAPGLLPLDQLSLIKPIKDVDILDDDVVQQLGGVMEEAEVVDTDLLLDDQD   1121 - 1190
SVLLQGDAEL                                                               1191 - 1200
//

Text Mined References (21)

PMID Year Title
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21573134 2011 Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
18351453 2009 Functional identification of genes causing estrogen independence of human breast cancer cells.
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