| Tbio | N-terminal EF-hand calcium-binding protein 3 |
Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3.
The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 9.0e-09 |
| Astrocytoma, Pilocytic | 3081 | 1.2e-07 |
| glioblastoma | 5792 | 7.3e-06 |
| atypical teratoid/rhabdoid tumor | 357 | 2.3e-05 |
| psoriasis | 6694 | 1.7e-04 |
| adult high grade glioma | 3801 | 1.1e-03 |
| group 3 medulloblastoma | 4104 | 1.6e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.300 | 1.1e-03 |
| Astrocytoma, Pilocytic | -1.400 | 1.2e-07 |
| atypical teratoid/rhabdoid tumor | -1.100 | 2.3e-05 |
| glioblastoma | -1.100 | 7.3e-06 |
| group 3 medulloblastoma | -1.100 | 1.6e-02 |
| osteosarcoma | 2.016 | 9.0e-09 |
| psoriasis | -1.400 | 1.7e-04 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MACAGLLTVCLLRPPAPQPQPQTPRHPQLAPDPGPAGHTLFQDVFRRADKNDDGKLSFEEFQNYFADGVL 1 - 70 SLGELQELFSGIDGHLTDNLETEKLCDYFSEHLGVYRPVLAALESLNRAVLAAMDATKLEYERASKVDQF 71 - 140 VTRFLLRETVSQLQALQSSLEGASDTLEAQAHGWRSDAESVEAQSRLCGSRRAGRRALRSVSRSSTWSPG 141 - 210 SSDTGRSSEAEMQWRLQVNRLQELIDQLECKVRAVGPGPHKGGPSWYPPEPGPCWRPGPHSVPSQAPRLE 211 - 280 PLREEDLAKGPDLHILMAQRQVQVAEEGLQDFHRALRCYVDFTGAQSHCLHVSAQKMLDGASFTLYEFWQ 281 - 350 DEASWRRHQQSPGSKAFQRILIDHLRAPDTLTTVFFPASWWIMNNN 351 - 396 //
