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Tbio
AIFM3
Apoptosis-inducing factor 3

Protein Summary
Description
Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399163
  • ENSP00000382116
  • ENSG00000183773
  • ENST00000399167
  • ENSP00000382120
  • ENST00000405089
  • ENSP00000385800
  • ENST00000440238
  • ENSP00000390798

Symbol
  • AIFL
  • AIFL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
cell type or tissue
0.74
molecular function
0.67
cellular component
0.65
transcription factor
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.61   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.61   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0