| Tbio | Spermatogenesis-associated protein 13 |
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 6.3e-19 |
| ependymoma | 4679 | 2.4e-09 |
| juvenile dermatomyositis | 1187 | 3.3e-09 |
| osteosarcoma | 7950 | 2.2e-08 |
| Astrocytoma, Pilocytic | 3081 | 3.2e-07 |
| glioblastoma | 5792 | 5.9e-05 |
| pediatric high grade glioma | 1064 | 1.3e-04 |
| medulloblastoma, large-cell | 6241 | 1.9e-03 |
| interstitial cystitis | 2312 | 1.9e-03 |
| primary Sjogren syndrome | 735 | 5.0e-03 |
| group 3 medulloblastoma | 4104 | 8.4e-03 |
| ovarian cancer | 8520 | 1.6e-02 |
| progressive supranuclear palsy | 676 | 3.9e-02 |
| aldosterone-producing adenoma | 665 | 3.9e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Chronic obstructive pulmonary disease | 184 | 0.0 | 1.8 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Lissencephaly | 69 | 3.174 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| aldosterone-producing adenoma | -1.029 | 3.9e-02 |
| Astrocytoma, Pilocytic | 1.700 | 3.2e-07 |
| ependymoma | 1.400 | 2.4e-09 |
| glioblastoma | 1.200 | 5.9e-05 |
| group 3 medulloblastoma | -1.400 | 8.4e-03 |
| interstitial cystitis | 1.300 | 1.9e-03 |
| juvenile dermatomyositis | 1.268 | 3.3e-09 |
| medulloblastoma, large-cell | -1.200 | 1.9e-03 |
| non-small cell lung cancer | -1.410 | 6.3e-19 |
| osteosarcoma | 1.660 | 2.2e-08 |
| ovarian cancer | 1.400 | 1.6e-02 |
| pediatric high grade glioma | 1.100 | 1.3e-04 |
| primary Sjogren syndrome | 1.300 | 5.0e-03 |
| progressive supranuclear palsy | -1.100 | 3.9e-02 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG |
MTSASPEDQNAPVGCPKGARRRRPISVIGGVSLYGTNQTEELDNLLTQPASRPPMPAHQVPPYKAVSARF 1 - 70 RPFTFSQSTPIGLDRVGRRRQMRASNVSSDGGTEPSALVDDNGSEEDFSYEDLCQASPRYLQPGGEQLAI 71 - 140 NELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEEL 141 - 210 SENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVA 211 - 280 QLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMK 281 - 350 QGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACL 351 - 420 INERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDL 421 - 490 LRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQACADER 491 - 560 RRVQEDKEMGMEISENQKKLAMLNAQKAGHGKSKGYNRCPVAPPHQGLHPIHQRHITMPTSVPQQQVFGL 561 - 630 AEPKRKSSLFWHTFNRLTPFRK 631 - 652 //
