Tbio CMTM3 CKLF-like MARVEL transmembrane domain-containing protein 3

Protein Summary

Description

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96MX0
• A6NCL9
• Q8IUU8
• Q8IWQ6
• Q8IYE2
• Q8IZ39
• Q8IZ59

Gene Name

• CMTM3

Ensembl ID

• ENST00000361909
• ENSP00000354579
• ENSG00000140931
• ENST00000424011
• ENSP00000400482
• ENST00000562707
• ENSP00000455758
• ENST00000565922
• ENSP00000456426
• ENST00000567572
• ENSP00000455851

Symbol

• CKLFSF3
• BNAS2
• CKLFSF3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
kinase perturbation	0.81
PubMedID	0.8
transcription factor binding site profile	0.79
transcription factor	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 121   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0