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Tbio
PRICKLE1
Prickle-like protein 1

Protein Summary
Description
Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345127
  • ENSP00000345064
  • ENSG00000139174
  • ENST00000445766
  • ENSP00000398947
  • ENST00000455697
  • ENSP00000401060
  • ENST00000548696
  • ENSP00000448359
  • ENST00000552240
  • ENSP00000449819
  • ENST00000639566
  • ENSP00000492332
  • ENST00000639589
  • ENSP00000491051
  • ENST00000639958
  • ENSP00000492644
  • ENST00000640055
  • ENSP00000492763
  • ENST00000640132
  • ENSP00000491228

Symbol
  • RILP
  • RILP
  • EPM1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
biological process
0.89
PubMedID
0.83
kinase perturbation
0.81
transcription factor
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.37   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.37   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0