Tbio ZFP42 Zinc finger protein 42 homolog

Protein Summary

Description

Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity).

Uniprot Accession IDs

• Q96MM3
• D3DP65
• Q8WXE2
• Zfp-42

Gene Name

• ZFP42

Ensembl ID

• ENST00000326866
• ENSP00000317686
• ENSG00000179059
• ENST00000509524
• ENSP00000424662
• ENST00000618147
• ENSP00000483363

Symbol

• REX1
• ZNF754
• REX1
• REX-1
• ZNF754
• zfp-42

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.67
biological process	0.59
gene perturbation	0.59
virus perturbation	0.59
transcription factor	0.52

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Zinc Finger Protein 42 Homolog

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Zinc Finger Protein 42 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.13   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 328   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.13   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0