Tbio STAC3 SH3 and cysteine-rich domain-containing protein 3

Protein Summary

Description

Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels (PubMed:23736855, PubMed:29078335). Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (By similarity). Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:29078335). The protein encoded by this gene is a component of the excitation-contraction coupling machinery of muscles. This protein is a member of the Stac gene family and contains an N-terminal cysteine-rich domain and two SH3 domains. Mutations in this gene are a cause of Native American myopathy. [provided by RefSeq, Nov 2013]

Uniprot Accession IDs

• Q96MF2
• B4DUK9
• Q96HU5

Gene Name

• STAC3

Ensembl ID

• ENST00000332782
• ENSP00000329200
• ENSG00000185482
• ENST00000546246
• ENSP00000441515
• ENST00000554578
• ENSP00000452068

Symbol

• NAM
• MYPBB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	0.82
virus perturbation	0.64
tissue sample	0.59
cell type or tissue	0.56
cell line	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.4   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 73   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.4   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0