Property Summary

NCBI Gene PubMed Count 29
PubMed Score 21.27
PubTator Score 15.16

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
acute quadriplegic myopathy 1157 4.48093206584145E-8
tuberculosis 1563 4.46979867781694E-7
atypical teratoid / rhabdoid tumor 4369 2.02918011383169E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 6.4679288414859E-5
ependymoma 2514 1.75899851926321E-4
group 4 medulloblastoma 1875 2.44175952237821E-4
Breast cancer 3099 2.89768076150992E-4
ovarian cancer 8492 3.16403342512652E-4
glioblastoma 5572 4.39354988113861E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 7.7585881273689E-4
pituitary cancer 1972 0.00119919693690202
pancreatic cancer 2300 0.00152808632135811
primary pancreatic ductal adenocarcinoma 1271 0.00188532697017916
ulcerative colitis 2087 0.00682716554491348
medulloblastoma, large-cell 6234 0.00959444979183179
primitive neuroectodermal tumor 3031 0.0118329530150098
astrocytic glioma 2241 0.024580245804588
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0324777123251231
invasive ductal carcinoma 2950 0.0344522599432669
acute myeloid leukemia 785 0.0446815450616405
Disease Target Count Z-score Confidence
Kidney disease 397 0.0 1.0



Accession Q96LR5
Symbols UBCH8


PANTHER Protein Class (1)



  Ortholog (3)

Species Source
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Anole lizard OMA Inparanoid

 IMPC Term (1)

Gene RIF (10)

26020062 rs7612463 UBE2E2 single nucleotide polymorphism is associated with type 2 diabetes mellitus in a Chinese Han population.
25337779 Study found lack of association between UBE2E2 gene polymorphism (rs7612463) and type 2 diabetes mellitus in a Saudi population
23862583 The genetic variants of UBE2E2 are associated with gestational diabetes mellitus and fasting blood glucose.
20818381 Single nucleotide polymorphism in UBE2E2 is associated with type 2 diabetes.
20818381 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
18649358 Observational study of gene-disease association. (HuGE Navigator)
15545318 Ubiquitin charging can function as a nuclear import trigger, and identify a novel link between E2 regulation and karyopherin-mediated transport.
15485925 Ubc8 is a major ISG15-conjugating enzyme responsible for protein ISGylation upon interferon stimulation
11786535 Siah proteins function as E3 ubiquitin-protein ligases

AA Sequence


Text Mined References (38)

PMID Year Title
26020062 2015 Association between UBE2E2 variant rs7612463 and type 2 diabetes mellitus in a Chinese Han population.
25416956 2014 A proteome-scale map of the human interactome network.
25337779 2014 Lack of association between UBE2E2 gene polymorphism (rs7612463) and type 2 diabetes mellitus in a Saudi population.
24927181 2014 Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
24509480 2014 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
24446487 2014 E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24132900 2013 Genome-wide association study of atypical psychosis.
23945395 2014 Genome-wide association study identifies three novel loci for type 2 diabetes.
23862583 2013 Putative association between UBE2E2 polymorphisms and the risk of gestational diabetes mellitus.