Property Summary

NCBI Gene PubMed Count 12
PubMed Score 11.69
PubTator Score 12.87

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
osteosarcoma 7933 1.95975313811383E-7
tuberculosis and treatment for 3 months 327 1.5060399537882E-6
invasive ductal carcinoma 2950 0.0014847414145803
medulloblastoma, large-cell 6234 0.00200433413965852
primary Sjogren syndrome 789 0.00236056155340039
interstitial cystitis 2299 0.0101895835065046
Disease Target Count Z-score Confidence
Stargardt disease 7 3.022 1.5

Expression

  Differential Expression (6)

Disease log2 FC p
osteosarcoma -2.229 0.000
medulloblastoma, large-cell -1.200 0.002
tuberculosis and treatment for 3 months 2.000 0.000
interstitial cystitis 1.800 0.010
primary Sjogren syndrome 1.400 0.002
invasive ductal carcinoma 1.300 0.001

Synonym

Accession Q96LC7 A8K1I5 A8K3C7 C9JJ33 C9JM10 F8W917 Q3MIR5 Q6UXI8 Q96G54 Q96LC8 Siglec-10
Symbols SLG2
PRO940
SIGLEC-10

Gene

  Ortholog (2)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid

 CSPA Cell Line (1)

Gene RIF (4)

PMID Text
25450598 Siglec-10 is associated with decreased survival and impaired NK cell function in human hepatocellular carcinoma (HCC).
20237496 Observational study of gene-disease association. (HuGE Navigator)
19861682 Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium
17672918 the apparent occurrence of an unusual TG 3' splice site in intron 11 is discussed

AA Sequence

MLLPLLLSSLLGGSQAMDGRFWIRVQESVMVPEGLCISVPCSFSYPRQDWTGSTPAYGYWFKAVTETTKG      1 - 70
APVATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVRYNFMNDGFFLKVT     71 - 140
ALTQKPDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTGAALSSQGTKPTTSHFSVLSFTPRPQDHN    141 - 210
TDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADS    211 - 280
QPPATLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVM    281 - 350
VSQANRTVLENLGNGTSLPVLEGQSLCLVCVTHSSPPARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHE    351 - 420
GEFTCHARHPLGSQHVSLSLSVHYSPKLLGPSCSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQD    421 - 490
SFEVTPSSAGPWANSSLSLHGGLSSGLRLRCEAWNVHGAQSGSILQLPDKKGLISTAFSNGAFLGIGITA    491 - 560
LLFLCLALIIMKILPKRRTQTETPRPRFSRHSTILDYINVVPTAGPLAQKRNQKATPNSPRTPLPPGAPS    561 - 630
PESKKNQKKQYQLPSFPEPKSSTQAPESQESQEELHYATLNFPGVRPRPEARMPKGTQADYAEVKFQ       631 - 697
//

Text Mined References (14)

PMID Year Title
25450598 2015 Siglec-10 is associated with survival and natural killer cell dysfunction in hepatocellular carcinoma.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
19861682 2009 Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate.
17672918 2007 Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15057824 2004 The DNA sequence and biology of human chromosome 19.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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