Tbio SIGLEC10 Sialic acid-binding Ig-like lectin 10

Protein Summary

Description

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity). SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]

Uniprot Accession IDs

• Q96LC7
• A8K1I5
• A8K3C7
• C9JJ33
• C9JM10
• F8W917
• Q3MIR5
• Q6UXI8
• Q96G54
• Q96LC8
• Siglec-10

Gene Name

• SIGLEC10

Ensembl ID

• ENST00000339313
• ENSP00000345243
• ENSG00000142512
• ENST00000353836
• ENSP00000342389
• ENST00000436984
• ENSP00000414324
• ENST00000439889
• ENSP00000389132
• ENST00000441969
• ENSP00000408387
• ENST00000442846
• ENSP00000395475

Symbol

• SLG2
• SLG2
• PRO940
• SIGLEC-10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
tissue sample	0.65
kinase	0.62
tissue	0.62
cell line	0.59

Protein Classes

PANTHER Classes

Protein / Structural Protein / Myelin Protein / Sialic Acid-binding Ig-like Lectin 10

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Sialic Acid-binding Ig-like Lectin 10

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Sialic Acid-binding Ig-like Lectin 10

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / Sialic Acid-binding Ig-like Lectin 10

Protein / Cell Adhesion Molecule / Immunoglobulin Superfamily Cell Adhesion Molecule / Sialic Acid-binding Ig-like Lectin 10

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Sialic Acid-binding Ig-like Lectin 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.01   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 287   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.01   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0