FCRL1
Fc receptor-like protein 1
Protein Summary
May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
- ENST00000358292
- ENSP00000351039
- ENSG00000163534
- ENST00000368176
- ENSP00000357158
- ENST00000491942
- ENSP00000418130
- FCRH1
- IFGP1
- IRTA5
- FCRH1
- IFGP1
- IRTA5
- CD307a
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.62 | ||
microRNA | 0.62 | ||
disease | 0.54 | ||
cell type or tissue | 0.52 | ||
tissue | 0.48 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.17 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 181 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.17 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 181 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0