| Tbio | Rho-related GTP-binding protein RhoV |
Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2798 | 5.21228136558378E-16 |
| atypical teratoid / rhabdoid tumor | 4369 | 1.61290468612393E-6 |
| glioblastoma | 5572 | 1.74856783333546E-5 |
| lung adenocarcinoma | 2714 | 1.39956357264867E-4 |
| interstitial cystitis | 2299 | 2.3815446602257E-4 |
| nasopharyngeal carcinoma | 1056 | 9.67137354909414E-4 |
| adult high grade glioma | 2148 | 0.00148459773854245 |
| ductal carcinoma in situ | 1745 | 0.0119738286220923 |
| fibroadenoma | 557 | 0.0482719425203195 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | -1.200 | 0.000 |
| glioblastoma | -1.200 | 0.000 |
| non-small cell lung cancer | 1.693 | 0.000 |
| fibroadenoma | 1.700 | 0.048 |
| interstitial cystitis | -1.300 | 0.000 |
| adult high grade glioma | -1.200 | 0.001 |
| lung adenocarcinoma | 1.800 | 0.000 |
| nasopharyngeal carcinoma | -1.100 | 0.001 |
| ductal carcinoma in situ | 1.100 | 0.012 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Pig | OMA EggNOG Inparanoid |
| Opossum | EggNOG Inparanoid |
| Platypus | OMA EggNOG Inparanoid |
| Chicken | OMA Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 24388711 | Authors propose that the RHOV gene could be validated as a diagnostic or prognostic marker for NSCLC, and that observed overexpression of RHOV might contribute to tumorigenesis. |
| 22339630 | CDC42 homologous protein does not enhance the level of Ser60 phosphorylation in Pak6. (RHO V protein) |
| 17355222 | Results demonstrate a novel mechanism of signal termination mediated by the Rho-family GTPases Chp and Cdc42, which results in ubiquitin-mediated degradation of one of their direct effectors, Pak1. |
| 15664990 | Data suggest that Chp is implicated in cell transformation, and the unique amino and carboxyl termini of Chp represent atypical mechanisms of regulation of Rho GTPase function. |
| 11956592 | cloning and characterization of WRCH2 on human chromosome 15q15 |
| PMID | Year | Title |
|---|---|---|
| 24388711 | 2013 | The RHOV gene is overexpressed in human non-small cell lung cancer. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 22589738 | 2012 | Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. |
| 22339630 | 2012 | Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV. |
| 17355222 | 2007 | Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp. |
| 17035353 | 2007 | Evolution of the Rho family of ras-like GTPases in eukaryotes. |
| 16752908 | 2006 | Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins. |
| 15664990 | 2005 | Critical and distinct roles of amino- and carboxyl-terminal sequences in regulation of the biological activity of the Chp atypical Rho GTPase. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
| More... |
