Property Summary

NCBI Gene PubMed Count 11
PubMed Score 14.88
PubTator Score 15.71

Knowledge Summary


No data available


  Differential Expression (9)

Disease log2 FC p
atypical teratoid / rhabdoid tumor -1.200 1.6e-06
glioblastoma -1.200 1.7e-05
non-small cell lung cancer 1.693 5.2e-16
fibroadenoma 1.700 4.8e-02
interstitial cystitis -1.300 2.4e-04
adult high grade glioma -1.200 1.5e-03
lung adenocarcinoma 1.800 1.4e-04
nasopharyngeal carcinoma -1.100 9.7e-04
ductal carcinoma in situ 1.100 1.2e-02

Gene RIF (5)

24388711 Authors propose that the RHOV gene could be validated as a diagnostic or prognostic marker for NSCLC, and that observed overexpression of RHOV might contribute to tumorigenesis.
22339630 CDC42 homologous protein does not enhance the level of Ser60 phosphorylation in Pak6. (RHO V protein)
17355222 Results demonstrate a novel mechanism of signal termination mediated by the Rho-family GTPases Chp and Cdc42, which results in ubiquitin-mediated degradation of one of their direct effectors, Pak1.
15664990 Data suggest that Chp is implicated in cell transformation, and the unique amino and carboxyl termini of Chp represent atypical mechanisms of regulation of Rho GTPase function.
11956592 cloning and characterization of WRCH2 on human chromosome 15q15

AA Sequence

RLEKKLNAKGVRTLSRCRWKKFFCFV                                                211 - 236

Text Mined References (13)

PMID Year Title
24388711 2013 The RHOV gene is overexpressed in human non-small cell lung cancer.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22589738 2012 Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
22339630 2012 Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV.
17355222 2007 Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp.
17035353 2007 Evolution of the Rho family of ras-like GTPases in eukaryotes.
16752908 2006 Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins.
15664990 2005 Critical and distinct roles of amino- and carboxyl-terminal sequences in regulation of the biological activity of the Chp atypical Rho GTPase.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11956592 2002 Molecular cloning and characterization of WRCH2 on human chromosome 15q15.
11839775 2002 The Rho GTPase family: a Racs to Wrchs story.
9778532 1998 Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton.