Property Summary

NCBI Gene PubMed Count 16
PubMed Score 43.46
PubTator Score 161.88

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (4)

Disease Target Count
Malignant neoplasm of breast 63
Disease Target Count P-value
psoriasis 6685 8.98770309725555E-258
ulcerative colitis 2087 1.12187219114567E-8
malignant mesothelioma 3163 3.02614908041005E-6
tuberculosis 1563 1.78246930864515E-5
lung carcinoma 2844 6.9311927922468E-4
lung cancer 4473 0.0037501831722145
active Crohn's disease 918 0.0105027688185688
Disease Target Count Z-score Confidence
Breast cancer 3099 0.0 2.0
Disease Target Count Z-score Confidence
Lysinuric protein intolerance 15 3.262 1.6

Expression

  Differential Expression (7)

Disease log2 FC p
malignant mesothelioma -2.400 0.000
tuberculosis -2.400 0.000
lung cancer -1.800 0.004
active Crohn's disease 3.313 0.011
psoriasis 7.100 0.000
lung carcinoma -1.600 0.001
ulcerative colitis 5.100 0.000

Synonym

Accession Q96KP6 A1A574 A8K2Z4 B4DVF5 B4E023 Q96PQ3 Q9H780
Symbols LIND
ABIN-3

Gene

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Platypus OMA EggNOG
Chicken OMA EggNOG
Xenopus OMA EggNOG

Gene RIF (10)

PMID Text
23383108 A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of TNFAIP3 interacting protein 3 (TNIP3) in peptide-treated PBMCs
22093807 recombinant transgene facilitates the transcription of pro-inflammatory cytokines in fibroblast-like synoviocytes in rheumatoid arthritis
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
19617629 adiponectin augmented the expression of A20, suppressor of cytokine signaling (SOCS) 3, B-cell CLL/lymphoma (BCL) 3, TNF receptor-associated factor (TRAF) 1, and TNFAIP3-interacting protein (TNIP) 3.
19464428 This review defines ABIN-3 based on three different parameters: ability to bind A20; ability to inhibit NF-kappaB activation upon overexpression; the presence of specific short amino acid regions of strong homology, designated ABIN homology domains.
18081698 Enhanced expression of ABIN-3 in monocytes is associated with sepsis
17485448 ABIN-3 is, thus, an IL-10-induced gene product capable of attenuating NF-kappaB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions.
17088249 ABIN-3 is a novel negative feedback regulator of LPS-induced NF-kappaB activation

AA Sequence

MAHFVQGTSRMIAAESSTEHKECAEPSTRKNLMNSLEQKIRCLEKQRKELLEVNQQWDQQFRSMKELYER      1 - 70
KVAELKTKLDAAERFLSTREKDPHQRQRKDDRQREDDRQRDLTRDRLQREEKEKERLNEELHELKEENKL     71 - 140
LKGKNTLANKEKEHYECEIKRLNKALQDALNIKCSFSEDCLRKSRVEFCHEEMRTEMEVLKQQVQIYEED    141 - 210
FKKERSDRERLNQEKEELQQINETSQSQLNRLNSQIKACQMEKEKLEKQLKQMYCPPCNCGLVFHLQDPW    211 - 280
VPTGPGAVQKQREHPPDYQWYALDQLPPDVQHKANGLSSVKKVHP                             281 - 325
//

Text Mined References (18)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
23468962 2013 A genome-wide scan for breast cancer risk haplotypes among African American women.
22093807 2012 A pro-inflammatory role for A20 and ABIN family proteins in human fibroblast-like synoviocytes in rheumatoid arthritis.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19617629 2009 Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10.
19464428 2009 ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling.
18212736 2008 Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins.
18081698 Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappaB.
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