Property Summary

NCBI Gene PubMed Count 44
PubMed Score 252.40
PubTator Score 107.75

Knowledge Summary

Patent (57,704)


  Disease Sources (3)

Disease Target Count P-value
non-small cell lung cancer 2798 4.96489105911374E-29
Breast cancer 3099 1.51779316868511E-14
glioblastoma 5572 9.63761393121799E-14
atypical teratoid/rhabdoid tumor 1095 4.02109549028742E-13
group 3 medulloblastoma 2254 6.15958760452433E-10
pediatric high grade glioma 2712 9.27000321748783E-10
medulloblastoma, large-cell 6234 6.35239522195238E-9
lung cancer 4473 1.21378163510346E-7
oligodendroglioma 2849 2.47262301972188E-7
primitive neuroectodermal tumor 3031 3.33837488628423E-7
astrocytoma 1493 7.66765966080441E-7
adrenocortical carcinoma 1427 1.31486522574021E-6
posterior fossa group A ependymoma 1511 1.71429402817217E-6
breast carcinoma 1614 4.64155286372976E-6
pilocytic astrocytoma 3086 4.83919180773536E-5
lung adenocarcinoma 2714 6.03666488607356E-5
psoriasis 6685 7.66226552473111E-5
nasopharyngeal carcinoma 1056 9.52363517498245E-5
invasive ductal carcinoma 2950 1.04995397592415E-4
pancreatic cancer 2300 1.99499382520976E-4
ulcerative colitis 2087 3.30225512867566E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 8.40466631334638E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0010287610603488
ductal carcinoma in situ 1745 0.00146529384412937
Atopic dermatitis 944 0.00204502429298555
ovarian cancer 8492 0.00402963274737361
interstitial cystitis 2299 0.00461433607337495
pituitary cancer 1972 0.00801637268537403
Endometriosis 535 0.0109703229163982
primary Sjogren syndrome 789 0.0301850535451674



Accession Q96KB5 B4DX68 D3DST2 Q9NPD9 Q9NYL7 Q9NZK6
Symbols SPK



PANTHER Protein Class (3)



  Ortholog (12)

Gene RIF (31)

26503118 Overexpression of Nrf2 inhibited the PBK/TOPK KD-induced decrease in cdc2 and cyclin B expression and cell cycle arrest, and blocked ROS production and apoptosis.
25909225 The in vitro data have been consistent with a role for PBK/TOPK in facilitating invasion in prostate cancer. PBK could be a prognostic biomarker for prostate cancer that would discriminate aggressive prostate cancer from indolent disease.
25881543 TOPK was speculated to be one of a potential marker and therapeutic target in advanced prostate cancer
25687885 TOPK, overexpressed in colorectal cancer, enhances the resistance of colorectal cancer cells to anoikis.
25575812 Authors identified TOPK/PBK, in vitro and in vivo, as the master ZFP linker kinase. Furthermore, they show precise temporal correlation between TOPK activating phosphorylation by Cdk1 and linker phosphorylation in mitosis.
25550851 PBK/TOPK expression is closely associated with cervical cancer and cervical intraepithelial neoplasia, which may be served as a useful target for tumor diagnosis and immunotherapy.
25466965 PDZ-binding kinase/T-LAK cell-originated protein kinase correlates with mutant p53 and affects cell proliferation and viability as well as prognosis in lung adenocarcinoma
24629784 Study findings suggest that the PBK/TOPK mRNA/protein expression is specific to human bladder cancer and might be used as a novel target for development of cancer immunotherapy and diagnostic biomarker.
24440499 TOPK protein upregulates iNOS gene expression in T cell leukemia Jurkat cells or macrophage leukemic Raw 264.7 cells via NF-kappaB activation in response to LPS, and might act as a critical effector in LPS/TLR4-mediated signaling cascade.
24025073 PBK/TOPK expression is positively correlated with Ki67 and p53 expression, and can be used as an independent prognostic factor in non-small-cell lung cancer.

AA Sequence


Text Mined References (53)

PMID Year Title
26503118 2015 PBK/TOPK mediates promyelocyte proliferation via Nrf2-regulated cell cycle progression and apoptosis.
25909225 2015 PBK/TOPK enhances aggressive phenotype in prostate cancer via ?-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion.
25881543 2015 TOPK is highly expressed in circulating tumor cells, enabling metastasis of prostate cancer.
25687885 2015 CXCL8, overexpressed in colorectal cancer, enhances the resistance of colorectal cancer cells to anoikis.
25575812 2015 Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins.
25550851 2014 Expression of PBK/TOPK in cervical cancer and cervical intraepithelial neoplasia.
25466965 2015 PBK/TOPK expression correlates with mutant p53 and affects patients' prognosis and cell proliferation and viability in lung adenocarcinoma.
24629784 2014 Expression of PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK) in human urinary bladder transitional cell carcinoma.
24440499 2014 Activation of TOPK by lipopolysaccharide promotes induction of inducible nitric oxide synthase through NF-?B activity in leukemia cells.
24025073 2013 PBK/TOPK expression in non-small-cell lung cancer: its correlation and prognostic significance with Ki67 and p53 expression.