| Tchem | Ubiquitin carboxyl-terminal hydrolase 47 |
Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 1.1e-08 |
| ovarian cancer | 8520 | 9.2e-07 |
| tuberculosis | 2010 | 1.5e-05 |
| inflammatory breast cancer | 286 | 2.2e-04 |
| glioblastoma | 5792 | 2.8e-04 |
| osteosarcoma | 7950 | 5.2e-04 |
| invasive ductal carcinoma | 2951 | 2.1e-03 |
| adult high grade glioma | 3801 | 2.2e-03 |
| group 4 medulloblastoma | 1855 | 4.0e-03 |
| progressive supranuclear palsy | 676 | 6.1e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 7.0e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 7.1e-03 |
| primary pancreatic ductal adenocarcinoma | 1109 | 9.1e-03 |
| medulloblastoma, large-cell | 6241 | 9.7e-03 |
| ependymoma | 4679 | 1.0e-02 |
| oligodendroglioma | 2850 | 3.1e-02 |
| Rheumatoid arthritis | 1191 | 3.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.100 | 2.2e-03 |
| atypical teratoid / rhabdoid tumor | -1.200 | 7.1e-03 |
| ependymoma | 1.200 | 1.0e-02 |
| glioblastoma | -1.400 | 2.8e-04 |
| group 4 medulloblastoma | 1.100 | 4.0e-03 |
| inflammatory breast cancer | -1.200 | 2.2e-04 |
| intraductal papillary-mucinous adenoma (... | 1.300 | 7.0e-03 |
| invasive ductal carcinoma | -1.300 | 2.1e-03 |
| lung adenocarcinoma | -1.300 | 1.1e-08 |
| medulloblastoma, large-cell | -1.100 | 9.7e-03 |
| oligodendroglioma | 1.100 | 3.1e-02 |
| osteosarcoma | -1.383 | 5.2e-04 |
| ovarian cancer | -1.300 | 9.2e-07 |
| primary pancreatic ductal adenocarcinoma | 1.044 | 9.1e-03 |
| progressive supranuclear palsy | -1.200 | 6.1e-03 |
| Rheumatoid arthritis | 1.400 | 3.9e-02 |
| tuberculosis | -1.300 | 1.5e-05 |
CHEMBL2159508
pIC50 6.00
CHEMBL2159504
pIC50 6.06
CHEMBL2159503
pIC50 6.28
CHEMBL2159505
pIC50 6.30
CHEMBL2159507
pIC50 6.46
MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERITLNLPASTPV 1 - 70 RKLFEDVANKVGYINGTFDLVWGNGINTADMAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQILLE 71 - 140 DSSAGEDSVHDRFIGPLPREGSGGSTSDYVSQSYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTP 141 - 210 EFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVM 211 - 280 FDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAF 281 - 350 IQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSTF 351 - 420 IDVEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSNDDGVDEGICLETNSGTEKISKSGLEKNSLIYELF 421 - 490 SVMVHSGSAAGGHYYACIKSFSDEQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLI 491 - 560 YRLKDPARNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPTKQVMMENKLEVHK 561 - 630 DKTLKEAVEMAYKMMDLEEVIPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETR 631 - 700 KPDQVFQSYKPGEVMVKVHVVDLKAESVAAPITVRAYLNQTVTEFKQLISKAIHLPAETMRIVLERCYND 701 - 770 LRLLSVSSKTLKAEGFFRSNKVFVESSETLDYQMAFADSHLWKLLDRHANTIRLFVLLPEQSPVSYSKRT 771 - 840 AYQKAGGDSGNVDDDCERVKGPVGSLKSVEAILEESTEKLKSLSLQQQQDGDNGDSSKSTETSDFENIES 841 - 910 PLNERDSSASVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADNAQIP 911 - 980 LANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGEMQYMYFKAEPYAADEGSGEGHK 981 - 1050 WLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYASNQEFESVRLNETLSSFSDDNKITIRLGRALKK 1051 - 1120 GEYRVKVYQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLELSIDRFRLRKKTWKNPGTVF 1121 - 1190 LDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAVLSRRWKPSEMKLDPFQEVVLESSSVDELREKLS 1191 - 1260 EISGIPLDDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDKTEELMELTDE 1261 - 1330 QRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDLTQD 1331 - 1375 //
