| Tchem | Ubiquitin carboxyl-terminal hydrolase 47 |
Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.
Comments
Property Summary
| NCBI Gene PubMed Count | 17 |
| Grant Count | 3 |
| R01 Count | 3 |
| Funding | $297,250.34 |
| PubMed Score | 5.85 |
| PubTator Score | 3.59 |
| Disease | log2 FC | p |
|---|---|---|
| Rheumatoid Arthritis | 1.400 | 0.039 |
| ependymoma | 1.200 | 0.010 |
| oligodendroglioma | 1.100 | 0.031 |
| osteosarcoma | -1.426 | 0.001 |
| atypical teratoid / rhabdoid tumor | -1.200 | 0.007 |
| glioblastoma | -1.400 | 0.000 |
| medulloblastoma, large-cell | -1.100 | 0.010 |
| primary pancreatic ductal adenocarcinoma | 1.044 | 0.009 |
| tuberculosis | -1.300 | 0.000 |
| intraductal papillary-mucinous adenoma (... | 1.300 | 0.007 |
| pediatric high grade glioma | -1.200 | 0.000 |
| group 4 medulloblastoma | 1.100 | 0.004 |
| lung adenocarcinoma | -1.300 | 0.000 |
| inflammatory breast cancer | -1.200 | 0.000 |
| progressive supranuclear palsy | -1.300 | 0.008 |
| invasive ductal carcinoma | -1.300 | 0.002 |
| ovarian cancer | -2.300 | 0.000 |
CHEMBL2159508
pIC50 6.00
CHEMBL2159504
pIC50 6.06
CHEMBL2159503
pIC50 6.28
CHEMBL2159505
pIC50 6.30
CHEMBL2159507
pIC50 6.46
| PMID | Text |
|---|---|
| 26169834 | USP47 is a deubiquitinase that prevents beta-catenin ubiquitination. |
| 26115687 | these results suggest that USP47 may play distinct roles in ubiquitin-mediated cellular processes via de-ubiquitinating enzymes activity. |
| 25429829 | miR-204-5p acts as a tumor suppressor in gastric cancer through inhibiting USP47 and RAB22A. |
| 25253721 | Data indicate that E-cadherin ubiquitination consistently increases after depletion of kinesin-like protein KIFC3 or ubiquitin-specific protease USP47. |
| 23904609 | The results of this study indicated that USP47 plays a crucial role in the control of axonal growth during neuronal development by antagonizing CHIP-mediated katanin-p60 degradation. |
| 21362556 | USP47 has a role in regulating DNA repair and maintaining genome integrity |
| 19966869 | USP47, a novel beta-Trcp interactor, regulates cell growth and survival, potentially providing a novel target for anticancer therapies. |
MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERITLNLPASTPV 1 - 70 RKLFEDVANKVGYINGTFDLVWGNGINTADMAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQILLE 71 - 140 DSSAGEDSVHDRFIGPLPREGSGGSTSDYVSQSYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTP 141 - 210 EFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVM 211 - 280 FDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAF 281 - 350 IQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSTF 351 - 420 IDVEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSNDDGVDEGICLETNSGTEKISKSGLEKNSLIYELF 421 - 490 SVMVHSGSAAGGHYYACIKSFSDEQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLI 491 - 560 YRLKDPARNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPTKQVMMENKLEVHK 561 - 630 DKTLKEAVEMAYKMMDLEEVIPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETR 631 - 700 KPDQVFQSYKPGEVMVKVHVVDLKAESVAAPITVRAYLNQTVTEFKQLISKAIHLPAETMRIVLERCYND 701 - 770 LRLLSVSSKTLKAEGFFRSNKVFVESSETLDYQMAFADSHLWKLLDRHANTIRLFVLLPEQSPVSYSKRT 771 - 840 AYQKAGGDSGNVDDDCERVKGPVGSLKSVEAILEESTEKLKSLSLQQQQDGDNGDSSKSTETSDFENIES 841 - 910 PLNERDSSASVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADNAQIP 911 - 980 LANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGEMQYMYFKAEPYAADEGSGEGHK 981 - 1050 WLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYASNQEFESVRLNETLSSFSDDNKITIRLGRALKK 1051 - 1120 GEYRVKVYQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLELSIDRFRLRKKTWKNPGTVF 1121 - 1190 LDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAVLSRRWKPSEMKLDPFQEVVLESSSVDELREKLS 1191 - 1260 EISGIPLDDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDKTEELMELTDE 1261 - 1330 QRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDLTQD 1331 - 1375 //
| PMID | Year | Title |
|---|---|---|
| 26169834 | 2015 | Deubiquitinase USP47/UBP64E Regulates ?-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling. |
| 26115687 | 2015 | Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47. |
| 25429829 | 2015 | MicroRNA-204-5p inhibits gastric cancer cell proliferation by downregulating USP47 and RAB22A. |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 25253721 | 2014 | Minus end-directed motor KIFC3 suppresses E-cadherin degradation by recruiting USP47 to adherens junctions. |
| 24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
| 23904609 | 2013 | USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate katanin-p60-mediated axonal growth. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 21362556 | 2011 | USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase ?. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| More... |
