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Tchem Ubiquitin carboxyl-terminal hydrolase 47

Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.

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Property Summary

NCBI Gene PubMed Count 17
PubMed Score 5.85
PubTator Score 3.59

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
ovarian cancer 8492 6.60602837804505E-12
lung adenocarcinoma 2714 1.11088166123127E-8
tuberculosis 1563 1.50252038646081E-5
inflammatory breast cancer 404 2.23224892474626E-4
glioblastoma 5572 2.7974423421164E-4
pediatric high grade glioma 2712 4.2119175409223E-4
osteosarcoma 7933 8.38433502287332E-4
invasive ductal carcinoma 2950 0.00208267985515206
group 4 medulloblastoma 1875 0.00397483550151853
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00698084478777409
atypical teratoid / rhabdoid tumor 4369 0.00706643554896553
progressive supranuclear palsy 674 0.0084102035425495
primary pancreatic ductal adenocarcinoma 1271 0.00914066017152978
medulloblastoma, large-cell 6234 0.00970855178879754
ependymoma 2514 0.0104270686899652
oligodendroglioma 2849 0.0306272857653555
Rheumatoid Arthritis 1171 0.0390010503707335

Expression

  Differential Expression (17)

Disease log2 FC p
Rheumatoid Arthritis 1.400 0.039
ependymoma 1.200 0.010
oligodendroglioma 1.100 0.031
osteosarcoma -1.426 0.001
atypical teratoid / rhabdoid tumor -1.200 0.007
glioblastoma -1.400 0.000
medulloblastoma, large-cell -1.100 0.010
primary pancreatic ductal adenocarcinoma 1.044 0.009
tuberculosis -1.300 0.000
intraductal papillary-mucinous adenoma (... 1.300 0.007
pediatric high grade glioma -1.200 0.000
group 4 medulloblastoma 1.100 0.004
lung adenocarcinoma -1.300 0.000
inflammatory breast cancer -1.200 0.000
progressive supranuclear palsy -1.300 0.008
invasive ductal carcinoma -1.300 0.002
ovarian cancer -2.300 0.000

Synonym

Accession Q96K76 B3KXF5 E9PM46 Q658U0 Q86Y73 Q8TEP6 Q9BWI0 Q9NWN1
Symbols TRFP

Gene

USP47

  Ortholog (14)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Fruitfly OMA Inparanoid

 GO Function (2)

 GO Component (3)

 GO Process (12)

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 Compartment GO Term (20)

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 IMPC Term (7)

 MGI Term (4)

 HCA RNA Cell Line (56)

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Pathway (5)

 UniProt Keyword (13)

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Ligand (5)  

Structure of CHEMBL2159508

CHEMBL2159508
pIC50 6.00

Structure of CHEMBL2159504

CHEMBL2159504
pIC50 6.06

Structure of CHEMBL2159503

CHEMBL2159503
pIC50 6.28

Structure of CHEMBL2159505

CHEMBL2159505
pIC50 6.30

Structure of CHEMBL2159507

CHEMBL2159507
pIC50 6.46

Gene RIF (7)

PMID Text
26169834 USP47 is a deubiquitinase that prevents beta-catenin ubiquitination.
26115687 these results suggest that USP47 may play distinct roles in ubiquitin-mediated cellular processes via de-ubiquitinating enzymes activity.
25429829 miR-204-5p acts as a tumor suppressor in gastric cancer through inhibiting USP47 and RAB22A.
25253721 Data indicate that E-cadherin ubiquitination consistently increases after depletion of kinesin-like protein KIFC3 or ubiquitin-specific protease USP47.
23904609 The results of this study indicated that USP47 plays a crucial role in the control of axonal growth during neuronal development by antagonizing CHIP-mediated katanin-p60 degradation.
21362556 USP47 has a role in regulating DNA repair and maintaining genome integrity
19966869 USP47, a novel beta-Trcp interactor, regulates cell growth and survival, potentially providing a novel target for anticancer therapies.

AA Sequence 

MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERITLNLPASTPV      1 - 70
RKLFEDVANKVGYINGTFDLVWGNGINTADMAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQILLE     71 - 140
DSSAGEDSVHDRFIGPLPREGSGGSTSDYVSQSYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTP    141 - 210
EFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVM    211 - 280
FDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAF    281 - 350
IQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSTF    351 - 420
IDVEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSNDDGVDEGICLETNSGTEKISKSGLEKNSLIYELF    421 - 490
SVMVHSGSAAGGHYYACIKSFSDEQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLI    491 - 560
YRLKDPARNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPTKQVMMENKLEVHK    561 - 630
DKTLKEAVEMAYKMMDLEEVIPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETR    631 - 700
KPDQVFQSYKPGEVMVKVHVVDLKAESVAAPITVRAYLNQTVTEFKQLISKAIHLPAETMRIVLERCYND    701 - 770
LRLLSVSSKTLKAEGFFRSNKVFVESSETLDYQMAFADSHLWKLLDRHANTIRLFVLLPEQSPVSYSKRT    771 - 840
AYQKAGGDSGNVDDDCERVKGPVGSLKSVEAILEESTEKLKSLSLQQQQDGDNGDSSKSTETSDFENIES    841 - 910
PLNERDSSASVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADNAQIP    911 - 980
LANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGEMQYMYFKAEPYAADEGSGEGHK    981 - 1050
WLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYASNQEFESVRLNETLSSFSDDNKITIRLGRALKK   1051 - 1120
GEYRVKVYQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLELSIDRFRLRKKTWKNPGTVF   1121 - 1190
LDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAVLSRRWKPSEMKLDPFQEVVLESSSVDELREKLS   1191 - 1260
EISGIPLDDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDKTEELMELTDE   1261 - 1330
QRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDLTQD                            1331 - 1375
//

Text Mined References (26)

PMID Year Title
26169834 2015 Deubiquitinase USP47/UBP64E Regulates ?-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling.
26115687 2015 Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47.
25429829 2015 MicroRNA-204-5p inhibits gastric cancer cell proliferation by downregulating USP47 and RAB22A.
25416956 2014 A proteome-scale map of the human interactome network.
25253721 2014 Minus end-directed motor KIFC3 suppresses E-cadherin degradation by recruiting USP47 to adherens junctions.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23904609 2013 USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate katanin-p60-mediated axonal growth.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21362556 2011 USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase ?.
21269460 2011 Initial characterization of the human central proteome.
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