Tchem | Ubiquitin carboxyl-terminal hydrolase 47 |
Comments
Disease | Target Count | P-value |
---|---|---|
ovarian cancer | 8492 | 6.60602837804505E-12 |
lung adenocarcinoma | 2714 | 1.11088166123127E-8 |
tuberculosis | 1563 | 1.50252038646081E-5 |
inflammatory breast cancer | 404 | 2.23224892474626E-4 |
glioblastoma | 5572 | 2.7974423421164E-4 |
pediatric high grade glioma | 2712 | 4.2119175409223E-4 |
osteosarcoma | 7933 | 8.38433502287332E-4 |
invasive ductal carcinoma | 2950 | 0.00208267985515206 |
group 4 medulloblastoma | 1875 | 0.00397483550151853 |
intraductal papillary-mucinous adenoma (IPMA) | 2956 | 0.00698084478777409 |
atypical teratoid / rhabdoid tumor | 4369 | 0.00706643554896553 |
progressive supranuclear palsy | 674 | 0.0084102035425495 |
primary pancreatic ductal adenocarcinoma | 1271 | 0.00914066017152978 |
medulloblastoma, large-cell | 6234 | 0.00970855178879754 |
ependymoma | 2514 | 0.0104270686899652 |
oligodendroglioma | 2849 | 0.0306272857653555 |
Rheumatoid Arthritis | 1171 | 0.0390010503707335 |
Disease | log2 FC | p |
---|---|---|
Rheumatoid Arthritis | 1.400 | 0.039 |
ependymoma | 1.200 | 0.010 |
oligodendroglioma | 1.100 | 0.031 |
osteosarcoma | -1.426 | 0.001 |
atypical teratoid / rhabdoid tumor | -1.200 | 0.007 |
glioblastoma | -1.400 | 0.000 |
medulloblastoma, large-cell | -1.100 | 0.010 |
primary pancreatic ductal adenocarcinoma | 1.044 | 0.009 |
tuberculosis | -1.300 | 0.000 |
intraductal papillary-mucinous adenoma (... | 1.300 | 0.007 |
pediatric high grade glioma | -1.200 | 0.000 |
group 4 medulloblastoma | 1.100 | 0.004 |
lung adenocarcinoma | -1.300 | 0.000 |
inflammatory breast cancer | -1.200 | 0.000 |
progressive supranuclear palsy | -1.300 | 0.008 |
invasive ductal carcinoma | -1.300 | 0.002 |
ovarian cancer | -2.300 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG Inparanoid |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
Fruitfly | OMA Inparanoid |
CHEMBL2159508
pIC50 6.00
CHEMBL2159504
pIC50 6.06
CHEMBL2159503
pIC50 6.28
CHEMBL2159505
pIC50 6.30
CHEMBL2159507
pIC50 6.46
PMID | Text |
---|---|
26169834 | USP47 is a deubiquitinase that prevents beta-catenin ubiquitination. |
26115687 | these results suggest that USP47 may play distinct roles in ubiquitin-mediated cellular processes via de-ubiquitinating enzymes activity. |
25429829 | miR-204-5p acts as a tumor suppressor in gastric cancer through inhibiting USP47 and RAB22A. |
25253721 | Data indicate that E-cadherin ubiquitination consistently increases after depletion of kinesin-like protein KIFC3 or ubiquitin-specific protease USP47. |
23904609 | The results of this study indicated that USP47 plays a crucial role in the control of axonal growth during neuronal development by antagonizing CHIP-mediated katanin-p60 degradation. |
21362556 | USP47 has a role in regulating DNA repair and maintaining genome integrity |
19966869 | USP47, a novel beta-Trcp interactor, regulates cell growth and survival, potentially providing a novel target for anticancer therapies. |
MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERITLNLPASTPV 1 - 70 RKLFEDVANKVGYINGTFDLVWGNGINTADMAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQILLE 71 - 140 DSSAGEDSVHDRFIGPLPREGSGGSTSDYVSQSYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTP 141 - 210 EFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVM 211 - 280 FDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAF 281 - 350 IQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSTF 351 - 420 IDVEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSNDDGVDEGICLETNSGTEKISKSGLEKNSLIYELF 421 - 490 SVMVHSGSAAGGHYYACIKSFSDEQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLI 491 - 560 YRLKDPARNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPTKQVMMENKLEVHK 561 - 630 DKTLKEAVEMAYKMMDLEEVIPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETR 631 - 700 KPDQVFQSYKPGEVMVKVHVVDLKAESVAAPITVRAYLNQTVTEFKQLISKAIHLPAETMRIVLERCYND 701 - 770 LRLLSVSSKTLKAEGFFRSNKVFVESSETLDYQMAFADSHLWKLLDRHANTIRLFVLLPEQSPVSYSKRT 771 - 840 AYQKAGGDSGNVDDDCERVKGPVGSLKSVEAILEESTEKLKSLSLQQQQDGDNGDSSKSTETSDFENIES 841 - 910 PLNERDSSASVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADNAQIP 911 - 980 LANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGEMQYMYFKAEPYAADEGSGEGHK 981 - 1050 WLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYASNQEFESVRLNETLSSFSDDNKITIRLGRALKK 1051 - 1120 GEYRVKVYQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLELSIDRFRLRKKTWKNPGTVF 1121 - 1190 LDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAVLSRRWKPSEMKLDPFQEVVLESSSVDELREKLS 1191 - 1260 EISGIPLDDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDKTEELMELTDE 1261 - 1330 QRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDLTQD 1331 - 1375 //
PMID | Year | Title |
---|---|---|
26169834 | 2015 | Deubiquitinase USP47/UBP64E Regulates ?-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling. |
26115687 | 2015 | Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47. |
25429829 | 2015 | MicroRNA-204-5p inhibits gastric cancer cell proliferation by downregulating USP47 and RAB22A. |
25416956 | 2014 | A proteome-scale map of the human interactome network. |
25253721 | 2014 | Minus end-directed motor KIFC3 suppresses E-cadherin degradation by recruiting USP47 to adherens junctions. |
24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
23904609 | 2013 | USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate katanin-p60-mediated axonal growth. |
23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
21362556 | 2011 | USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase ?. |
21269460 | 2011 | Initial characterization of the human central proteome. |
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