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Tbio
ZFYVE19
Abscission/NoCut checkpoint regulator

Protein Summary
Description
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299173
  • ENSP00000299173
  • ENSG00000166140
  • ENST00000336455
  • ENSP00000337824
  • ENST00000355341
  • ENSP00000347498
  • ENST00000564258
  • ENSP00000457617

Symbol
  • ANCHR
  • MPFYVE
  • ANCHR
  • MPFYVE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue sample
0.67
transcription factor binding site profile
0.64
histone modification site profile
0.62
cell type or tissue
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.42   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.42   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0