Property Summary

NCBI Gene PubMed Count 23
PubMed Score 261.22
PubTator Score 17.94

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
non-small cell lung cancer 2798 1.12010626634811E-26
tuberculosis 1563 7.38960410130573E-9
ovarian cancer 8492 2.02538704496558E-7
ulcerative colitis 2087 1.7744784026091E-5
cystic fibrosis 1670 3.44841187632134E-5
acute quadriplegic myopathy 1157 6.77930018319812E-5
pilocytic astrocytoma 3086 4.44464961704851E-4
medulloblastoma, large-cell 6234 0.00144542137834832
head and neck cancer 270 0.00236090860886226
group 4 medulloblastoma 1875 0.00265532133350777
active Crohn's disease 918 0.00656481493108209
gastric carcinoma 832 0.00667265386333619
primary pancreatic ductal adenocarcinoma 1271 0.00873295814220216
pancreatic cancer 2300 0.0102366783934335
esophageal adenocarcinoma 737 0.0176010007179145
Barrett's esophagus 185 0.035850294388239


  Differential Expression (16)

Disease log2 FC p
Barrett's esophagus -1.100 0.036
esophageal adenocarcinoma -2.200 0.018
cystic fibrosis -1.018 0.000
medulloblastoma, large-cell -2.000 0.001
acute quadriplegic myopathy -1.119 0.000
tuberculosis 2.000 0.000
primary pancreatic ductal adenocarcinoma 1.016 0.009
non-small cell lung cancer -1.822 0.000
active Crohn's disease -1.344 0.007
group 4 medulloblastoma -1.600 0.003
pilocytic astrocytoma 1.200 0.000
gastric carcinoma 1.700 0.007
ulcerative colitis -1.500 0.000
ovarian cancer 2.100 0.000
pancreatic cancer 1.100 0.010
head and neck cancer -1.100 0.002


Accession Q96JY6 D3DSR5 J3KNH4 Q7Z584 Q86WM8 Q8WZ29 Q9H4L9 Q9H7I2
Symbols SLIM



2PA1   3PDV  

  Ortholog (7)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid

Pathway (1)

Gene RIF (12)

26499308 The suppression of PDLIM2 expression significantly reduced cell proliferation, cell growth and neoplasm invasiveness in prostate cancer cells.
25681443 epigenetic repression of PDLIM2 can be reversed by 5-aza-2-deoxycytidine and vitamin D to suppress KSHV-associated cancer cell growth
24863845 PDLIM2 expression is essential for feedback regulation of the beta1-integrin-RhoA signalling axis and integration of cellular microenvironment signals with gene expression to control the polarity of breast epithelial acini structures.
24196835 PDLIM2 integrates cytoskeleton signaling with gene expression in epithelial differentiation by controlling the stability of key transcription factors and COP9 signalosome activity.
23584482 PDLIM2 was a direct target gene of 1,25(OH)2D3
21814175 Pdlim2 is a novel actin-regulating protein of podocyte foot processes that may have a role in the pathogenesis of glomerular diseases.
20838382 PDLIM2 binds to Tax directly, which was mediated by a putative alpa-helix motif of PDLIM2 at amino acids 236-254.
20185823 PDLIM2, an essential terminator of NF-kappaB activation, is repressed in both estrogen receptor-positive and estrogen receptor-negative breast cancer cells, suggesting one important mechanism for the constitutive activation of NF-kappaB.
19794962 Data show that the PDLIM2 repression was independent of the viral regulatory protein Tax because neither short-term induction nor long-term stable expression of Tax could downregulate PDLIM2 expression.
19052146 Suppression of PDLIM2 expression resulted in decreased cell adhesion, increased NF-kappaB transcription reporter activity, and increased LPS-induced TNF-alpha production.

AA Sequence

RA                                                                        351 - 352

Text Mined References (26)

PMID Year Title
26499308 2016 PDLIM2 suppression efficiently reduces tumor growth and invasiveness of human castration-resistant prostate cancer-like cells.
25681443 2015 Oncovirus Kaposi sarcoma herpesvirus (KSHV) represses tumor suppressor PDLIM2 to persistently activate nuclear factor ?B (NF-?B) and STAT3 transcription factors for tumorigenesis and tumor maintenance.
24863845 2014 Essential function for PDLIM2 in cell polarization in three-dimensional cultures by feedback regulation of the ?1-integrin-RhoA signaling axis.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24196835 2014 PDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome.
23584482 2014 PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
21814175 2011 Pdlim2 is a novel actin-regulating protein of podocyte foot processes.
21044950 2011 Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
20838382 2010 Molecular determinants of PDLIM2 in suppressing HTLV-I Tax-mediated tumorigenesis.