Tchem L3MBTL3 Lethal(3)malignant brain tumor-like protein 3

Protein Summary

Description

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity). This gene encodes a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. Members of this family function as methyl-lysine readers, which recognize methylated lysine residues on histone protein tails, and are associated with the repression of gene expression. The encoded protein may regulate hematopoiesis. Homozygous deletion of this gene has been observed in human patients with medulloblastoma. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• Q96JM7
• Q4VXE1
• Q5VUM9
• Q6P9B5
• H-l(3)mbt-like protein 3

Gene Name

• L3MBTL3

Ensembl ID

• ENST00000361794
• ENSP00000354526
• ENSG00000198945
• ENST00000368136
• ENSP00000357118
• ENST00000368139
• ENSP00000357121
• ENST00000526019
• ENSP00000436706
• ENST00000529410
• ENSP00000431962
• ENST00000533560
• ENSP00000437185

Symbol

• KIAA1798
• MBT1
• MBT1
• MBT-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.83
virus	0.66
viral protein	0.59
virus perturbation	0.59
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Lethal(3)malignant Brain Tumor-like Protein 3

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Lethal(3)malignant Brain Tumor-like Protein 3

DTO Classes

Protein / Epigenetic Regulator / Reader / Methyl-lysine/arginine Binding Protein / Mbt Domain / Lethal(3)malignant Brain Tumor-like Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.72   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 124   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.72   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 63

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0