Tbio MAML3 Mastermind-like protein 3

Protein Summary

Description

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.

Uniprot Accession IDs

• Q96JK9
• B2RNU9
• B3KVV7
• E7EVW8
• Mam-3

Gene Name

• MAML3

Ensembl ID

• ENST00000509479
• ENSP00000421180
• ENSG00000196782

Symbol

• KIAA1816
• GDN
• MAM2
• CAGH3
• ERDA3
• MAM-2
• TNRC3
• mam-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.83
microRNA	0.79
transcription factor	0.67
cell line	0.56
cell type or tissue	0.55

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Mastermind-like Protein 3

DTO Classes

Protein / Transcription Factor / Mastermind-like Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.92   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 204   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.92   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0