Tbio TMX3 Protein disulfide-isomerase TMX3

Protein Summary

Description

Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The canonical protein encoded by this gene has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This gene is expressed in many tissues but has its highest expression in heart and skeletal muscle. It is expressed in the retinal neuroepithelium and lens epithelium in the developing murine eye and haploinsufficiency of this gene in humans and zebrafish is associated with microphthalmia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]

Uniprot Accession IDs

• Q96JJ7
• B3KV75
• Q52LT7
• Q8N5J0
• Q9NWJ9

Gene Name

• TMX3

Ensembl ID

• ENST00000299608
• ENSP00000299608
• ENSG00000166479
• ENST00000562706
• ENSP00000457262

Symbol

• KIAA1830
• TXNDC10
• PDIA13
• TXNDC10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.74
transcription factor perturbation	0.74
tissue	0.73
cell type or tissue	0.62
tissue sample	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.85   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.85   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0