| Tbio | Protein disulfide-isomerase TMX3 |
Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase.
Comments
Property Summary
| NCBI Gene PubMed Count | 15 |
| Grant Count | 9 |
| R01 Count | 5 |
| Funding | $353,438.33 |
| PubMed Score | 5.29 |
| PubTator Score | 6.59 |
| Disease | log2 FC | p |
|---|---|---|
| juvenile dermatomyositis | 1.261 | 0.000 |
| intraductal papillary-mucinous neoplasm ... | 1.300 | 0.011 |
| ovarian cancer | -2.600 | 0.000 |
| PMID | Text |
|---|---|
| 20485507 | Haploinsufficiency for TMX3 results in a small eye phenotype and represents a novel genetic cause of microphthalmia and coloboma. |
| 19240061 | Observational study of gene-disease association. (HuGE Navigator) |
| 17881353 | analysis of TMX3 interdomain stabilization of the N-terminal redox-active domain |
| 15623505 | TMX3 is a thioredoxin-related transmembrane protein of the endoplasmic reticulum |
MAAWKSWTALRLCATVVVLDMVVCKGFVEDLDESFKENRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEM 1 - 70 KSIGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQ 71 - 140 QMFEHMQKRHRVFFVYVGGESPLKEKYIDAASELIVYTYFFSASEEVVPEYVTLKEMPAVLVFKDETYFV 141 - 210 YDEYEDGDLSSWINRERFQNYLAMDGFLLYELGDTGKLVALAVIDEKNTSVEHTRLKSIIQEVARDYRDL 211 - 280 FHRDFQFGHMDGNDYINTLLMDELTVPTVVVLNTSNQQYFLLDRQIKNVEDMVQFINNILDGTVEAQGGD 281 - 350 SILQRLKRIVFDAKSTIVSIFKSSPLMGCFLFGLPLGVISIMCYGIYTADTDGGYIEERYEVSKSENENQ 351 - 420 EQIEESKEQQEPSSGGSVVPTVQEPKDVLEKKKD 421 - 454 //
| PMID | Year | Title |
|---|---|---|
| 25944712 | 2015 | N-terminome analysis of the human mitochondrial proteome. |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 23728934 | 2013 | Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| 20485507 | 2010 | A male with unilateral microphthalmia reveals a role for TMX3 in eye development. |
| 19995400 | 2010 | Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. |
| 19240061 | 2009 | Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. |
| 19159218 | 2009 | Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| 17881353 | 2007 | Structure-function analysis of the endoplasmic reticulum oxidoreductase TMX3 reveals interdomain stabilization of the N-terminal redox-active domain. |
| More... |
