Tbio | Engulfment and cell motility protein 2 |
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Comments
Disease | Target Count | P-value |
---|---|---|
ovarian cancer | 8492 | 5.00525047378451E-7 |
atypical teratoid / rhabdoid tumor | 4369 | 6.14674706238804E-5 |
medulloblastoma, large-cell | 6234 | 5.38520731008404E-4 |
Pick disease | 1893 | 6.24065933112439E-4 |
oligodendroglioma | 2849 | 0.0016857211657969 |
subependymal giant cell astrocytoma | 2287 | 0.00261167064921956 |
ependymoma | 2514 | 0.00572426500755673 |
astrocytic glioma | 2241 | 0.0101800183140978 |
group 4 medulloblastoma | 1875 | 0.0112167651155809 |
esophageal adenocarcinoma | 737 | 0.0195207517873976 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Epidermolysis bullosa dystrophica | 6 | 3.387 | 1.7 |
Disease | log2 FC | p |
---|---|---|
astrocytic glioma | 1.100 | 0.010 |
ependymoma | 1.100 | 0.006 |
oligodendroglioma | 1.100 | 0.002 |
esophageal adenocarcinoma | -1.100 | 0.020 |
atypical teratoid / rhabdoid tumor | -1.400 | 0.000 |
medulloblastoma, large-cell | -1.600 | 0.001 |
group 4 medulloblastoma | 1.200 | 0.011 |
subependymal giant cell astrocytoma | -2.438 | 0.003 |
Pick disease | -1.100 | 0.001 |
ovarian cancer | 2.200 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA Inparanoid |
Mouse | OMA Inparanoid |
Rat | OMA Inparanoid |
Dog | OMA Inparanoid |
Horse | OMA Inparanoid |
Cow | OMA Inparanoid |
Pig | OMA Inparanoid |
Chicken | OMA Inparanoid |
Xenopus | OMA Inparanoid |
PMID | Text |
---|---|
25332238 | Axl has a role in phosphorylating the Elmo scaffold proteins to promote Rac activation and cell invasion |
23184944 | uncovered a role for ELMO in the recruitment of ACF7 to the membrane to promote microtubule capture and stability |
22568984 | Through its association with ELMO2, ILK plays key roles in the regulation of Rho GTPases and cross-talk pathways between adhesion and growth factor receptors. |
18602983 | Observational study of gene-disease association. (HuGE Navigator) |
MPPPSDIVKVAIEWPGANAQLLEIDQKRPLASIIKEVCDGWSLPNPEYYTLRYADGPQLYITEQTRSDIK 1 - 70 NGTILQLAISPSRAARQLMERTQSSNMETRLDAMKELAKLSADVTFATEFINMDGIIVLTRLVESGTKLL 71 - 140 SHYSEMLAFTLTAFLELMDHGIVSWDMVSITFIKQIAGYVSQPMVDVSILQRSLAILESMVLNSQSLYQK 141 - 210 IAEEITVGQLISHLQVSNQEIQTYAIALINALFLKAPEDKRQDMANAFAQKHLRSIILNHVIRGNRPIKT 211 - 280 EMAHQLYVLQVLTFNLLEERMMTKMDPNDQAQRDIIFELRRIAFDAESDPSNAPGSGTEKRKAMYTKDYK 281 - 350 MLGFTNHINPAMDFTQTPPGMLALDNMLYLAKVHQDTYIRIVLENSSREDKHECPFGRSAIELTKMLCEI 351 - 420 LQVGELPNEGRNDYHPMFFTHDRAFEELFGICIQLLNKTWKEMRATAEDFNKVMQVVREQITRALPSKPN 421 - 490 SLDQFKSKLRSLSYSEILRLRQSERMSQDDFQSPPIVELREKIQPEILELIKQQRLNRLCEGSSFRKIGN 491 - 560 RRRQERFWYCRLALNHKVLHYGDLDDNPQGEVTFESLQEKIPVADIKAIVTGKDCPHMKEKSALKQNKEV 561 - 630 LELAFSILYDPDETLNFIAPNKYEYCIWIDGLSALLGKDMSSELTKSDLDTLLSMEMKLRLLDLENIQIP 631 - 700 EAPPPIPKEPSSYDFVYHYG 701 - 720 //
PMID | Year | Title |
---|---|---|
25332238 | 2015 | Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion. |
24567399 | 2014 | G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates. |
23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
23184944 | 2013 | ELMO recruits actin cross-linking family 7 (ACF7) at the cell membrane for microtubule capture and stabilization of cellular protrusions. |
22568984 | Emerging role of ILK and ELMO2 in the integration of adhesion and migration pathways. | |
21269460 | 2011 | Initial characterization of the human central proteome. |
20679435 | 2010 | Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. |
18602983 | 2008 | Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. |
16381901 | 2006 | The LIFEdb database in 2006. |
16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
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