| Tbio | Engulfment and cell motility protein 2 |
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Vascular Malformation, Primary Intraosseous | 1 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 2.9e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 6.1e-05 |
| medulloblastoma, large-cell | 6241 | 5.4e-04 |
| Pick disease | 1894 | 6.2e-04 |
| oligodendroglioma | 2850 | 1.7e-03 |
| subependymal giant cell astrocytoma | 2287 | 2.6e-03 |
| ependymoma | 4679 | 5.7e-03 |
| astrocytic glioma | 2597 | 1.0e-02 |
| group 4 medulloblastoma | 1855 | 1.1e-02 |
| esophageal adenocarcinoma | 737 | 2.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Adenoid hypertrophy | 6 | 3.994 | 2.0 |
| Umbilical hernia | 93 | 3.768 | 1.9 |
| Recessive dystrophic epidermolysis bullosa | 2 | 3.439 | 1.7 |
| Fibrous dysplasia | 15 | 3.176 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | 1.100 | 1.0e-02 |
| atypical teratoid / rhabdoid tumor | -1.400 | 6.1e-05 |
| ependymoma | 1.100 | 5.7e-03 |
| esophageal adenocarcinoma | -1.100 | 2.0e-02 |
| group 4 medulloblastoma | 1.200 | 1.1e-02 |
| medulloblastoma, large-cell | -1.600 | 5.4e-04 |
| oligodendroglioma | 1.100 | 1.7e-03 |
| ovarian cancer | 1.400 | 2.9e-05 |
| Pick disease | -1.100 | 6.2e-04 |
| subependymal giant cell astrocytoma | -2.438 | 2.6e-03 |
MPPPSDIVKVAIEWPGANAQLLEIDQKRPLASIIKEVCDGWSLPNPEYYTLRYADGPQLYITEQTRSDIK 1 - 70 NGTILQLAISPSRAARQLMERTQSSNMETRLDAMKELAKLSADVTFATEFINMDGIIVLTRLVESGTKLL 71 - 140 SHYSEMLAFTLTAFLELMDHGIVSWDMVSITFIKQIAGYVSQPMVDVSILQRSLAILESMVLNSQSLYQK 141 - 210 IAEEITVGQLISHLQVSNQEIQTYAIALINALFLKAPEDKRQDMANAFAQKHLRSIILNHVIRGNRPIKT 211 - 280 EMAHQLYVLQVLTFNLLEERMMTKMDPNDQAQRDIIFELRRIAFDAESDPSNAPGSGTEKRKAMYTKDYK 281 - 350 MLGFTNHINPAMDFTQTPPGMLALDNMLYLAKVHQDTYIRIVLENSSREDKHECPFGRSAIELTKMLCEI 351 - 420 LQVGELPNEGRNDYHPMFFTHDRAFEELFGICIQLLNKTWKEMRATAEDFNKVMQVVREQITRALPSKPN 421 - 490 SLDQFKSKLRSLSYSEILRLRQSERMSQDDFQSPPIVELREKIQPEILELIKQQRLNRLCEGSSFRKIGN 491 - 560 RRRQERFWYCRLALNHKVLHYGDLDDNPQGEVTFESLQEKIPVADIKAIVTGKDCPHMKEKSALKQNKEV 561 - 630 LELAFSILYDPDETLNFIAPNKYEYCIWIDGLSALLGKDMSSELTKSDLDTLLSMEMKLRLLDLENIQIP 631 - 700 EAPPPIPKEPSSYDFVYHYG 701 - 720 //
