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Tbio
SPG11
Spatacsin

Protein Summary
Description
May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261866
  • ENSP00000261866
  • ENSG00000104133
  • ENST00000535302
  • ENSP00000445278
  • ENST00000558319
  • ENSP00000453599

Symbol
  • KIAA1840
  • ALS5
  • CMT2X
  • KIAA1840
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
cellular component
0.83
transcription factor perturbation
0.8
histone modification site profile
0.78
transcription factor binding site profile
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.46   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.46   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0