Tbio VPS50 Syndetin

Protein Summary

Description

Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).

Uniprot Accession IDs

• Q96JG6
• B3KX22
• D1MQ00
• F5H5U7
• Q75N07
• Q8WVK3
• Q9H5C6

Gene Name

• VPS50

Ensembl ID

• ENST00000251739
• ENSP00000251739
• ENSG00000004766
• ENST00000305866
• ENSP00000307666
• ENST00000544910
• ENSP00000443104

Symbol

• CCDC132
• KIAA1861
• VPS54L
• CCDC132

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.57   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 139   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.57   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0