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Tbio
LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

Protein Summary
Description
Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273261
  • ENSP00000273261
  • ENSG00000144749
  • ENST00000383703
  • ENSP00000373208
  • ENST00000631853
  • ENSP00000488729
  • ENSG00000282243
  • ENST00000633161
  • ENSP00000488182

Symbol
  • LIG1
  • LIG1
  • LIG-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.99
PubMedID
0.91
kinase perturbation
0.88
transcription factor binding site profile
0.83


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.11   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.11   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0