Property Summary

NCBI Gene PubMed Count 10
PubMed Score 3.84
PubTator Score 4.59

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count
Down syndrome 548
Muscle Weakness 92
Disease Target Count P-value
non-small cell lung cancer 2798 2.65849218066275E-30
breast carcinoma 1614 3.05105511126238E-22
lung adenocarcinoma 2714 1.55257588398991E-16
Breast cancer 3099 5.06063555610295E-11
sonic hedgehog group medulloblastoma 1482 6.17527581583898E-9
ependymoma 2514 4.21434860085395E-8
pilocytic astrocytoma 3086 7.48883600365775E-8
pediatric high grade glioma 2712 5.59568764071232E-6
primitive neuroectodermal tumor 3031 7.50018819388732E-6
intraductal papillary-mucinous adenoma (IPMA) 2956 1.39457200134957E-5
atypical teratoid / rhabdoid tumor 4369 1.44761681281115E-5
intraductal papillary-mucinous carcinoma (IPMC) 2988 2.38857050489129E-5
invasive ductal carcinoma 2950 3.87287743262343E-5
ductal carcinoma in situ 1745 9.21534674428229E-5
ulcerative colitis 2087 1.25833609348062E-4
ovarian cancer 8492 4.03529820769641E-4
glioblastoma 5572 4.28066798248909E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 4.97075963110484E-4
adrenocortical carcinoma 1427 0.001994978219887
aldosterone-producing adenoma 664 0.0164407418380435
medulloblastoma, large-cell 6234 0.0173563492241998




  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG
Xenopus OMA EggNOG Inparanoid

Gene RIF (2)

24981926 New CYYR1 alternative isoforms were identified and characterized.
17442112 A new "subtle" splicing isoform (CAG+) of CYYR1 mRNA, the sequence & expression of this gene were defined in a series of NE tumors. This CAG+ codon determines the presence of an Ala residue at the exon 3/exon 4 junction of the CYYR1 mRNA.

AA Sequence

QRSPPPPYPGNARK                                                            141 - 154

Text Mined References (11)

PMID Year Title
24981926 2014 Characterization of human gene locus CYYR1: a complex multi-transcript system.
22837378 2012 Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
17442112 2007 Sequence, "subtle" alternative splicing and expression of the CYYR1 (cysteine/tyrosine-rich 1) mRNA in human neuroendocrine tumors.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12062809 2002 Cysteine and tyrosine-rich 1 (CYYR1), a novel unpredicted gene on human chromosome 21 (21q21.2), encodes a cysteine and tyrosine-rich protein and defines a new family of highly conserved vertebrate-specific genes.
12036297 2002 Nineteen additional unpredicted transcripts from human chromosome 21.
10830953 2000 The DNA sequence of human chromosome 21.