Property Summary

NCBI Gene PubMed Count 96
PubMed Score 103.53
PubTator Score 118.67

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
non-small cell lung cancer 2798 1.47060226113013E-16
posterior fossa group A ependymoma 1511 2.61133889071709E-13
Breast cancer 3099 1.72052048042307E-11
atypical teratoid / rhabdoid tumor 4369 3.4392035625042E-7
ovarian cancer 8492 3.30560212556502E-6
lung cancer 4473 4.96552073722317E-6
malignant mesothelioma 3163 1.91978589837838E-5
cystic fibrosis 1670 3.44841187632134E-5
group 4 medulloblastoma 1875 7.78459668404038E-5
osteosarcoma 7933 1.24968701833542E-4
psoriasis 6685 1.30410000197448E-4
glioblastoma 5572 4.67862690259661E-4
Pick disease 1893 7.03101413285779E-4
pediatric high grade glioma 2712 0.00212228252872834
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00399185819683838
acute myeloid leukemia 785 0.00670317823586389
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00717909092253683
primitive neuroectodermal tumor 3031 0.0168517055895449
ductal carcinoma in situ 1745 0.0193394870022275
invasive ductal carcinoma 2950 0.0204790502952023
spina bifida 1064 0.0313034939502616
adrenocortical carcinoma 1427 0.0331621171049131
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0400470894733415
Polycystic Ovary Syndrome 335 0.04364317280387
Disease Target Count Z-score Confidence
Specific developmental disorder 2 0.0 1.0
Disease Target Count Z-score Confidence
Cancer 2346 3.465 1.7



Accession Q96IZ0 O75796 Q6FHY9 Q8N700
Symbols PAR4




  Ortholog (7)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (83)

26977019 Decreased PAR4 expression in breast cancer is associated with shorter survival. PAR4 suppresses growth and invasiveness of breast cancer cells.
26246468 Authors determined that PAR-4 induces cell apoptosis in response to stimuli, in vitro, but is also involved in the relocation of GRP78 from endoplasmic reticulum to the cell surface of ovarian cancer cell line.
25670650 These results suggest that Porphyromonas gingivalis activates PAR4 signaling pathways, leading proMMP9 over-expression and cellular invasion in oral squamous cell carcinoma cells.
25495701 PAR1-platelet releasate enhances vasculogenesis more potently than PAR4-platelet releasate, and the enhancements require a cooperation of multiple platelet-derived angiogenic regulators.
25373316 Data indicate that PAR1 and PAR4 activate common promigratory signalling pathways in Hep3B liver carcinoma cells including activation of the receptor tyrosine kinases Met and PDGFR, the formation of ROS and the inactivation of PTP1B.
25297082 These results indicate that the expression of PAR1 and PAR2 in esophageal squamous cell carcinoma is increased but PAR4 is decreased.
25195896 C-terminus of the rat homologue of Par-4 was crystallized and a 3.7 A resolution X-ray diffraction data set was collected
25001535 The cancer cell specific activity of Par-4 is elicited through intracellular as well as extracellular mechanisms.
24992930 a Par-4 mutant that is unable to bind Fbxo45 is stabilized and further enhances staurosporine-induced apoptosis.
24931006 our results indicate that the mechanism by which PAR-4 orchestrates the apoptotic process requires cleavage by caspase-8.

AA Sequence


Text Mined References (103)

PMID Year Title
26977019 2016 Prostate Apoptosis Response-4 (PAR4) Suppresses Growth and Invasion of Breast Cancer Cells and Is Positively Associated with Patient Survival.
26246468 2015 Role of PAR-4 in ovarian cancer.
25670650 2015 Involvement of protease-activated receptor 4 in over-expression of matrix metalloproteinase 9 induced by Porphyromonas gingivalis.
25495701 2015 PAR1-stimulated platelet releasate promotes angiogenic activities of endothelial progenitor cells more potently than PAR4-stimulated platelet releasate.
25373316 2015 Proteinase-activated receptor 1- and 4-promoted migration of Hep3B hepatocellular carcinoma cells depends on ROS formation and RTK transactivation.
25297082 2014 Protease-activated receptor (PAR)1, PAR2 and PAR4 expressions in esophageal squamous cell carcinoma.
25195896 2014 Cloning, expression, purification, crystallization and preliminary crystallographic analysis of the C-terminal domain of Par-4 (PAWR).
25001535 2014 Cancer-selective apoptosis by tumor suppressor par-4.
24992930 2014 Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.
24931006 2014 Caspase-8-mediated PAR-4 cleavage is required for TNF?-induced apoptosis.