Property Summary

NCBI Gene PubMed Count 81
PubMed Score 143.47
PubTator Score 111.84

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
Breast cancer 3099 2.50715249270192E-8
pituitary cancer 1972 1.00232332779279E-7
facioscapulohumeral dystrophy 286 4.30069541759319E-7
posterior fossa group A ependymoma 1511 5.6806772429555E-7
non-small cell lung cancer 2798 3.65635006140622E-6
lung carcinoma 2844 2.37246741385523E-5
primary pancreatic ductal adenocarcinoma 1271 5.89789842562385E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 1.39018039791376E-4
juvenile dermatomyositis 1189 1.75947785705302E-4
pancreatic cancer 2300 1.80352102898615E-4
Duchenne muscular dystrophy 602 3.8933383836443E-4
limb girdle muscular dystrophy 2A 156 6.27566263826268E-4
ovarian cancer 8492 0.00218178704577077
lung adenocarcinoma 2714 0.0028418233329211
subependymal giant cell astrocytoma 2287 0.00340849124139126
gastric carcinoma 832 0.00666710917480611
pilocytic astrocytoma 3086 0.00915090764619254
acute quadriplegic myopathy 1157 0.0103693439474208
interstitial cystitis 2299 0.0116517284751663
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0139161794868076
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.0140113009796755
Atopic dermatitis 944 0.0143581315912054
cystic fibrosis 1670 0.0166895891583921
diabetes mellitus 1663 0.0204234661083571
oligodendroglioma 2849 0.0210909274892611
interstitial lung disease 292 0.0294488810022768
ductal carcinoma in situ 1745 0.0403084182735765
group 3 medulloblastoma 2254 0.0430177542186214
pediatric high grade glioma 2712 0.0453522860562462
Disease Target Count Z-score Confidence
Obesity 616 0.0 1.0
Disease Target Count Z-score Confidence
Cancer 2346 4.23 2.1
Adenoma 165 3.602 1.8



Accession Q96HF1 B3KQR2 O14778 Q9HAP5 FRP-2
Symbols FRP-2


  Ortholog (13)

Gene RIF (63)

27042933 age-related increases in sFRP2 augment both angiogenesis and metastasis of melanoma cells
26763443 SFRP2 protein plays a role in the ultraviolet rays induced hyperpigmentary disorders.
26517501 Patients with Cytogenetically Normal Primary Acute Myeloid Leukemia and high sFRP2 expression had higher incidence of complete remission rate and better overall survival.
25788689 The distribution of Sfrp2 (and Sfrp1) in the eye is consistent with the idea that they modulate visual pathfinding and axon guidance.
25759530 A combination of GATA5 and SFRP2 methylation could be promising as a marker for the detection and diagnosis of colorectal cancers and adenomas.
25245632 Data suggest that overexpression of secreted frizzled-related protein 2 (sFRP2) gene in mesenchymal stem cells (hMSCs) might improve the therapeutic effectiveness of hMSC transplantation.
25197341 These findings suggest that decreased SFRP2 expression is associated with intermediate/poor karyotypes in acute myeloid leukemia
25189527 The role of SFRP2, as a functional tumor suppressor in the development of oral squamous cell carcinoma, is mediated through inhibition of the Wnt signaling pathway.
25107489 Aberrant methylation of APC gene was statistically significant associated with age over 50, DDK3 with male, SFRP4, WIF1, and WNT5a with increasing tumor stage SFRP4 and WIF1 with tumor differentiation and SFRP2 and SFRP5 with histological type
25053594 The risk size of SFRP2 hypermethylation from normal control to adenoma or polyp as well as from adenoma or polyp to colorectal cancer increased gradually

AA Sequence

REFKRISRSIRKLQC                                                           281 - 295

Text Mined References (81)

PMID Year Title
27042933 2016 sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.
26763443 2016 Secreted Frizzled-Related Protein 2 (sFRP2) Functions as a Melanogenic Stimulator; the Role of sFRP2 in UV-Induced Hyperpigmentary Disorders.
26517501 2015 Prognostic Significance of Secreted Frizzled-Related Protein 2 Expression in Cytogenetically Normal Primary Acute Myeloid Leukemia.
25788689 2015 Secreted frizzled related proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms.
25759530 2015 Combined detection of plasma GATA5 and SFRP2 methylation is a valid noninvasive biomarker for colorectal cancer and adenomas.
25245632 2015 Enhanced human mesenchymal stem cell survival under oxidative stress by overexpression of secreted frizzled-related protein 2 gene.
25197341 2014 Decreased SFRP2 expression is associated with intermediate and poor karyotypes in de novo acute myeloid leukemia.
25189527 2014 Secreted frizzled?related protein 2 is epigenetically silenced and functions as a tumor suppressor in oral squamous cell carcinoma.
25107489 2014 Promoter methylation analysis of WNT/?-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer.
25053594 2014 Variation risks of SFRP2 hypermethylation between precancerous disease and colorectal cancer.