Property Summary

NCBI Gene PubMed Count 17
PubMed Score 8.61
PubTator Score 6.87

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
non-small cell lung cancer 2798 1.53890000642093E-32
breast carcinoma 1614 8.38123921767705E-31
psoriasis 6685 8.5249885196578E-13
Breast cancer 3099 9.34653518503617E-12
glioblastoma 5572 1.36824731899954E-10
atypical teratoid/rhabdoid tumor 1095 3.79724259842757E-8
Pick disease 1893 7.99438424091081E-8
osteosarcoma 7933 9.7204664581042E-8
pediatric high grade glioma 2712 8.17654106236029E-7
tuberculosis 1563 1.11005385114357E-6
group 3 medulloblastoma 2254 1.15141418222015E-6
medulloblastoma, large-cell 6234 2.0663057989444E-6
lung adenocarcinoma 2714 4.8619341758539E-6
nasopharyngeal carcinoma 1056 3.50905150420305E-5
adrenocortical carcinoma 1427 4.79609758664863E-5
Atopic dermatitis 944 4.98405119004891E-5
invasive ductal carcinoma 2950 5.91500307275629E-5
pancreatic cancer 2300 6.34546369907849E-5
primitive neuroectodermal tumor 3031 1.9443737868488E-4
ovarian cancer 8492 2.84713149412728E-4
primary Sjogren syndrome 789 5.11915122406568E-4
pancreatic ductal adenocarcinoma liver metastasis 1795 8.00536534646195E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 8.66373807785654E-4
ductal carcinoma in situ 1745 0.00266447824254008
oligodendroglioma 2849 0.00290617908303799
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00424061718653611
ependymoma 2514 0.00498682024487136
astrocytic glioma 2241 0.00623231582179973
Endometriosis 535 0.00665278127062265
interstitial cystitis 2299 0.0075987056059395
Multiple myeloma 1328 0.00852040830368063
esophageal adenocarcinoma 737 0.0179350527878244
Disease Target Count Z-score Confidence
Klatskin's tumor 3 3.669 1.8



Accession Q96HE9 Q9NUZ7 Q9NXE9


  Ortholog (12)

Gene RIF (8)

26252227 PRR11 may be widely activated in human gastric cancer.
26162986 PRR11-SKA2 bidirectional transcription unit, which is a novel direct target of NF-Y, is essential for the accelerated proliferation and motility of lung cancer cells
25973065 Targeted depletion of PRR11 caused a dramatic cell cycle arrest followed by massive apoptotic cell death, and eventually resulted in a significant decrease in growth and viability in lung cancer cell lines.
25971332 Microarray analysis revealed that several genes involved in cell proliferation, cell adhesion, and cell migration were altered in PRR11-knockout cells.
25674234 we found that increased expression of proline-rich protein 11 (PRR11) was associated with the progression of breast cancer and that PRR11 protein levels were significantly elevated in breast cancer
25666944 Overexpression of PRR11 inhibits cell proliferation and induces premature chromatin condensation.
23246489 our results strongly demonstrated that this newly identified gene, PRR11, had a critical role in both cell cycle progression and tumorigenesis, and might serve as a novel potential target in the diagnosis and/or treatment of human lung cancer.
17672918 the apparent occurrence of an unusual TG 3' splice site in intron 10 is discussed

AA Sequence

LSTSSFDEQN                                                                351 - 360

Text Mined References (22)

PMID Year Title
26252227 2015 PRR11 Is a Prognostic Marker and Potential Oncogene in Patients with Gastric Cancer.
26162986 2015 The gene pair PRR11 and SKA2 shares a NF-Y-regulated bidirectional promoter and contributes to lung cancer development.
25973065 2015 RNAi-mediated silencing of praline-rich gene causes growth reduction in human lung cancer cells.
25971332 2015 The prognostic potential and oncogenic effects of PRR11 expression in hilar cholangiocarcinoma.
25674234 2014 Proline-rich protein 11 regulates epithelial-to-mesenchymal transition to promote breast cancer cell invasion.
25666944 2015 PRR11 regulates late-S to G2/M phase progression and induces premature chromatin condensation (PCC).
23246489 2013 PRR11 is a novel gene implicated in cell cycle progression and lung cancer.
23242552 2013 Global subcellular characterization of protein degradation using quantitative proteomics.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.