Tbio SLC39A13 Zinc transporter ZIP13

Protein Summary

Description

Acts as a zinc-influx transporter. This gene encodes a member of the LIV-1 subfamily of the ZIP transporter family. The encoded transmembrane protein functions as a zinc transporter. Mutations in this gene have been associated with the spondylocheiro dysplastic form of Ehlers-Danlos syndrome. Alternate transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• Q96H72
• D3DQR6
• D3DQR7
• E9PLY1
• E9PQV3
• Q659D9
• Q8N7C9
• Q8WV10

Gene Name

• SLC39A13

Ensembl ID

• ENST00000354884
• ENSP00000346956
• ENSG00000165915
• ENST00000362021
• ENSP00000354689

Symbol

• ZIP13
• ZIP13
• SCDEDS
• EDSSPD3
• LZT-Hs9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.87
kinase perturbation	0.84
histone modification site profile	0.72
transcription factor	0.7
molecular function	0.6

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Zinc Transporter Zip13

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc39 Family Of Metal Ion Transporters / Zinc Transporter Zip13

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.55   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 59   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.55   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0