| Tbio | Unconventional myosin-XIX |
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. MYO19 is involved in mitochondrial motility.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2798 | 1.88402570212863E-16 |
| lung adenocarcinoma | 2714 | 6.29204122415211E-10 |
| malignant mesothelioma | 3163 | 1.02842276215806E-6 |
| medulloblastoma, large-cell | 6234 | 7.04429735728656E-5 |
| group 3 medulloblastoma | 2254 | 3.81956141756246E-4 |
| lung cancer | 4473 | 4.85413266096779E-4 |
| intraductal papillary-mucinous adenoma (IPMA) | 2956 | 0.00210931296145097 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 0.00221154904604882 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 0.0193764707371013 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | 1.500 | 0.000 |
| medulloblastoma, large-cell | 1.300 | 0.000 |
| non-small cell lung cancer | 1.087 | 0.000 |
| intraductal papillary-mucinous adenoma (... | 1.800 | 0.002 |
| intraductal papillary-mucinous carcinoma... | 1.700 | 0.002 |
| intraductal papillary-mucinous neoplasm ... | 1.300 | 0.019 |
| lung cancer | 1.800 | 0.000 |
| group 3 medulloblastoma | 1.200 | 0.000 |
| lung adenocarcinoma | 1.400 | 0.000 |
| Species | Source |
|---|---|
| Mouse | OMA Inparanoid |
| Rat | OMA Inparanoid |
| Dog | OMA Inparanoid |
| Horse | OMA Inparanoid |
| Cow | OMA Inparanoid |
| Opossum | OMA Inparanoid |
| Chicken | OMA Inparanoid |
| Anole lizard | OMA Inparanoid |
| Xenopus | OMA Inparanoid |
MLQQVNGHNPGSDGQAREYLREDLQEFLGGEVLLYKLDDLTRVNPVTLETVLRCLQARYMADTFYTNAGC 1 - 70 TLVALNPFKPVPQLYSPELMREYHAAPQPQKLKPHVFTVGEQTYRNVKSLIEPVNQSIVVSGESGAGKTW 71 - 140 TSRCLMKFYAVVATSPASWESHKIAERIEQRILNSNPVMEAFGNACTLRNNNSSRFGKFIQLQLNRAQQM 141 - 210 TGAAVQTYLLEKTRVACQASSERNFHIFYQICKGASEDERLQWHLPEGAAFSWLPNPERSLEEDCFEVTR 211 - 280 EAMLHLGIDTPTQNNIFKVLAGLLHLGNIQFAASEDEAQPCQPMDDAKYSVRTAASLLGLPEDVLLEMVQ 281 - 350 IRTIRAGRQQQVFRKPCARAECDTRRDCLAKLIYARLFDWLVSVINSSICADTDSWTTFIGLLDVYGFES 351 - 420 FPDNSLEQLCINYANEKLQQHFVAHYLRAQQEEYAVEGLEWSFINYQDNQPCLDLIEGSPISICSLINEE 421 - 490 CRLNRPSSAAQLQTRIETALAGSPCLGHNKLSREPSFIVVHYAGPVRYHTAGLVEKNKDPIPPELTRLLQ 491 - 560 QSQDPLLMGLFPTNPKEKTQEEPPGQSRAPVLTVVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQGQAQT 561 - 630 FLQEEVLSQLEACGLVETIHISAAGFPIRVSHRNFVERYKLLRRLHPCTSSGPDSPYPAKGLPEWCPHSE 631 - 700 EATLEPLIQDILHTLPVLTQAAAITGDSAEAMPAPMHCGRTKVFMTDSMLELLECGRARVLEQCARCIQG 701 - 770 GWRRHRHREQERQWRAVMLIQAAIRSWLTRKHIQRLHAAATVIKRAWQKWRIRMACLAAKELDGVEEKHF 771 - 840 SQAPCSLSTSPLQTRLLEAIIRLWPLGLVLANTAMGVGSFQRKLVVWACLQLPRGSPSSYTVQTAQDQAG 841 - 910 VTSIRALPQGSIKFHCRKSPLRYADICPEPSPYSITGFNQILLERHRLIHVTSSAFTGLG 911 - 970 //
| PMID | Year | Title |
|---|---|---|
| 26659663 | 2016 | Myo19 is an outer mitochondrial membrane motor and effector of starvation-induced filopodia. |
| 25944712 | 2015 | N-terminome analysis of the human mitochondrial proteome. |
| 25447992 | 2014 | Myo19 ensures symmetric partitioning of mitochondria and coupling of mitochondrial segregation to cell division. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 19932026 | 2009 | Human Myo19 is a novel myosin that associates with mitochondria. |
| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. |
| 17877792 | 2007 | Drawing the tree of eukaryotic life based on the analysis of 2,269 manually annotated myosins from 328 species. |
| 16625196 | 2006 | DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| More... |
