| Tbio | Unconventional myosin-XIX |
Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 1.9e-16 |
| lung adenocarcinoma | 2716 | 1.9e-08 |
| malignant mesothelioma | 3232 | 1.0e-06 |
| medulloblastoma, large-cell | 6241 | 7.0e-05 |
| group 3 medulloblastoma | 4104 | 3.8e-04 |
| lung cancer | 4740 | 4.9e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.1e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 2.2e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| group 3 medulloblastoma | 1.200 | 3.8e-04 |
| intraductal papillary-mucinous adenoma (... | 1.800 | 2.1e-03 |
| intraductal papillary-mucinous carcinoma... | 1.700 | 2.2e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.300 | 1.9e-02 |
| lung adenocarcinoma | 1.100 | 1.9e-08 |
| lung cancer | 1.800 | 4.9e-04 |
| malignant mesothelioma | 1.500 | 1.0e-06 |
| medulloblastoma, large-cell | 1.300 | 7.0e-05 |
| non-small cell lung cancer | 1.087 | 1.9e-16 |
MLQQVNGHNPGSDGQAREYLREDLQEFLGGEVLLYKLDDLTRVNPVTLETVLRCLQARYMADTFYTNAGC 1 - 70 TLVALNPFKPVPQLYSPELMREYHAAPQPQKLKPHVFTVGEQTYRNVKSLIEPVNQSIVVSGESGAGKTW 71 - 140 TSRCLMKFYAVVATSPASWESHKIAERIEQRILNSNPVMEAFGNACTLRNNNSSRFGKFIQLQLNRAQQM 141 - 210 TGAAVQTYLLEKTRVACQASSERNFHIFYQICKGASEDERLQWHLPEGAAFSWLPNPERSLEEDCFEVTR 211 - 280 EAMLHLGIDTPTQNNIFKVLAGLLHLGNIQFAASEDEAQPCQPMDDAKYSVRTAASLLGLPEDVLLEMVQ 281 - 350 IRTIRAGRQQQVFRKPCARAECDTRRDCLAKLIYARLFDWLVSVINSSICADTDSWTTFIGLLDVYGFES 351 - 420 FPDNSLEQLCINYANEKLQQHFVAHYLRAQQEEYAVEGLEWSFINYQDNQPCLDLIEGSPISICSLINEE 421 - 490 CRLNRPSSAAQLQTRIETALAGSPCLGHNKLSREPSFIVVHYAGPVRYHTAGLVEKNKDPIPPELTRLLQ 491 - 560 QSQDPLLMGLFPTNPKEKTQEEPPGQSRAPVLTVVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQGQAQT 561 - 630 FLQEEVLSQLEACGLVETIHISAAGFPIRVSHRNFVERYKLLRRLHPCTSSGPDSPYPAKGLPEWCPHSE 631 - 700 EATLEPLIQDILHTLPVLTQAAAITGDSAEAMPAPMHCGRTKVFMTDSMLELLECGRARVLEQCARCIQG 701 - 770 GWRRHRHREQERQWRAVMLIQAAIRSWLTRKHIQRLHAAATVIKRAWQKWRIRMACLAAKELDGVEEKHF 771 - 840 SQAPCSLSTSPLQTRLLEAIIRLWPLGLVLANTAMGVGSFQRKLVVWACLQLPRGSPSSYTVQTAQDQAG 841 - 910 VTSIRALPQGSIKFHCRKSPLRYADICPEPSPYSITGFNQILLERHRLIHVTSSAFTGLG 911 - 970 //
