| Tbio | Cell division cycle-associated 7-like protein |
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 1.9e-26 |
| glioblastoma | 5792 | 1.7e-11 |
| oligodendroglioma | 2850 | 2.9e-10 |
| astrocytoma | 1146 | 2.8e-08 |
| Astrocytoma, Pilocytic | 3081 | 1.0e-07 |
| ovarian cancer | 8520 | 7.1e-06 |
| adult high grade glioma | 3801 | 1.3e-05 |
| medulloblastoma, large-cell | 6241 | 1.6e-05 |
| tuberculosis | 2010 | 5.9e-05 |
| group 3 medulloblastoma | 4104 | 7.9e-05 |
| Breast cancer | 3578 | 1.4e-04 |
| osteosarcoma | 7950 | 6.4e-04 |
| ependymoma | 4679 | 8.1e-04 |
| primitive neuroectodermal tumor | 3035 | 8.6e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.1e-03 |
| adrenocortical carcinoma | 1428 | 5.7e-03 |
| primary pancreatic ductal adenocarcinoma | 1109 | 8.3e-03 |
| pancreatic cancer | 2398 | 1.7e-02 |
| Disease | Target Count |
|---|---|
| Ciliary Dyskinesia, Primary, 7 | 2 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | 1.303 | 5.7e-03 |
| adult high grade glioma | 2.500 | 1.3e-05 |
| astrocytoma | 1.400 | 2.8e-08 |
| Astrocytoma, Pilocytic | 2.100 | 1.0e-07 |
| atypical teratoid / rhabdoid tumor | 1.800 | 2.1e-03 |
| Breast cancer | -1.500 | 1.4e-04 |
| ependymoma | 1.200 | 8.1e-04 |
| glioblastoma | 2.500 | 1.7e-11 |
| group 3 medulloblastoma | 1.700 | 7.9e-05 |
| lung carcinoma | -2.200 | 1.9e-26 |
| medulloblastoma, large-cell | 2.400 | 1.6e-05 |
| oligodendroglioma | 1.800 | 2.9e-10 |
| osteosarcoma | -2.971 | 6.4e-04 |
| ovarian cancer | -1.700 | 7.1e-06 |
| pancreatic cancer | -1.100 | 1.7e-02 |
| primary pancreatic ductal adenocarcinoma | -1.199 | 8.3e-03 |
| primitive neuroectodermal tumor | 1.400 | 8.6e-04 |
| tuberculosis | 1.100 | 5.9e-05 |
MELATRYQIPKEVADIFNAPSDDEEFVGFRDDVPMETLSSEESCDSFDSLESGKQQDVRFHSKYFTEELR 1 - 70 RIFIEDTDSETEDFAGFTQSDLNGKTNPEVMVVESDLSDDGKASLVSEEEEDEEEDKATPRRSRSRRSSI 71 - 140 GLRVAFQFPTKKLANKPDKNSSSEQLFSSARLQNEKKTILERKKDCRQVIQREDSTSESEDDSRDESQES 141 - 210 SDALLKRTMNIKENKAMLAQLLAELNSMPDFFPVRTPTSASRKKTVRRAFSEGQITRRMNPTRSARPPEK 211 - 280 FALENFTVSAAKFAEEFYSFRRRKTIGGKCREYRRRHRISSFRPVEDITEEDLENVAITVRDKIYDKVLG 281 - 350 NTCHQCRQKTIDTKTVCRNQGCCGVRGQFCGPCLRNRYGEDVRSALLDPDWVCPPCRGICNCSYCRKRDG 351 - 420 RCATGILIHLAKFYGYDNVKEYLESLQKELVEDN 421 - 454 //
