Tbio CERS2 Ceramide synthase 2

Protein Summary

Description

Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis. This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96G23
• D3DV06
• Q5SZE5
• Q9HD96
• Q9NW79
• CerS2

Gene Name

• CERS2

Ensembl ID

• ENST00000271688
• ENSP00000271688
• ENSG00000143418
• ENST00000368954
• ENSP00000357950

Symbol

• LASS2
• TMSG1
• L3
• LASS2
• SP260
• TMSG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
cellular component	0.79
transcription factor perturbation	0.74
microRNA	0.69
PubMedID	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.17   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 197   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.17   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0