Tbio CMTM7 CKLF-like MARVEL transmembrane domain-containing protein 7

Protein Summary

Description

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q96FZ5
• Q5VLK1

Gene Name

• CMTM7

Ensembl ID

• ENST00000334983
• ENSP00000335605
• ENSG00000153551
• ENST00000349718
• ENSP00000283621

Symbol

• CKLFSF7
• CKLFSF7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
transcription factor perturbation	0.94
small molecule perturbation	0.82
PubMedID	0.75
tissue sample	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.43   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 123   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.43   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0