Property Summary

NCBI Gene PubMed Count 20
PubMed Score 2.30
PubTator Score 7.47

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
psoriasis 6685 2.04973118538444E-58
lung carcinoma 2844 3.17298192717869E-16
posterior fossa group A ependymoma 1511 2.30724791525032E-9
Duchenne muscular dystrophy 602 7.74933882343268E-9
pilocytic astrocytoma 3086 9.14787935512872E-9
pancreatic cancer 2300 1.69898205108117E-7
adrenocortical carcinoma 1427 8.27304052058385E-7
cystic fibrosis 1670 6.28665459727453E-5
pituitary cancer 1972 8.5645212391838E-5
group 3 medulloblastoma 2254 2.30334045915714E-4
ovarian cancer 8492 3.26644189150725E-4
atypical teratoid/rhabdoid tumor 1095 4.77309745418355E-4
ductal carcinoma in situ 1745 0.0101179252573825
subependymal giant cell astrocytoma 2287 0.0108626613252348
primary pancreatic ductal adenocarcinoma 1271 0.0189054107899032
mucosa-associated lymphoid tissue lymphoma 480 0.0314067932174443
glioblastoma 5572 0.049130220923176



Accession Q96FQ6 A8K439 D3DV52 Q5RHS6
Symbols AAG13



2L50   2L51   3NXA  

  Ortholog (6)

 GO Process (1)

Gene RIF (4)

26353754 These results indicate that S100 calcium binding protein A16 is a differentiation promoting protein and might function as a tumor suppressor in oral squamous cell carcinoma.
25884418 Co-expression of S100A14 and S100A16 correlates with a poor prognosis in human breast cancer and promotes cancer cell invasion
25287362 S100A16 had a potential function to regulate some embryonic transcription factors to promote epithelial-mensenchymal transition in breast cancer cells which may be an important target site for the therapy of breast cancer.
21046186 The presence of hydrophobic interactions stronger than for other S100 proteins, present in the closed form of S100A16 between the third and fourth helices, likely make the closed structure of the second EF-hand particularly stable.

AA Sequence

DGRISFDEYWTLIGGITGPIAKLIHEQEQQSSS                                          71 - 103

Text Mined References (23)

PMID Year Title
26353754 2015 S100A16 promotes differentiation and contributes to a less aggressive tumor phenotype in oral squamous cell carcinoma.
25884418 2015 Co-expression of S100A14 and S100A16 correlates with a poor prognosis in human breast cancer and promotes cancer cell invasion.
25416956 2014 A proteome-scale map of the human interactome network.
25287362 2014 Up-regulation of S100A16 expression promotes epithelial-mesenchymal transition via Notch1 pathway in breast cancer.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
22658674 2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
21269460 2011 Initial characterization of the human central proteome.
21046186 2011 Structural characterization of human S100A16, a low-affinity calcium binder.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19199708 2009 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).