Tbio ELMOD3 ELMO domain-containing protein 3

Protein Summary

Description

Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity. This gene encodes a member of the engulfment and cell motility family of GTPase-activating proteins that regulate Arf GTPase proteins. Members of this family are defined by a conserved engulfment and cell motility domain. In rat cochlea, the encoded protein is found in stereocilia, kinocilia and cuticular plate of developing hair cells suggesting a function for this protein in cochlear sensory cells. An allelic variant of this family has been associated with autosomal recessive nonsyndromic deafness-88 in humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q96FG2
• B8ZZD6
• D6W5K4
• Q2M1K3
• Q2XSU3
• Q2XSU4
• Q8NAC1
• Q8TCK4
• Q8WV70
• Q8WY75
• Q9H6Q8

Gene Name

• ELMOD3

Ensembl ID

• ENST00000315658
• ENSP00000318264
• ENSG00000115459
• ENST00000393852
• ENSP00000377434
• ENST00000409013
• ENSP00000387139
• ENST00000409344
• ENSP00000386248
• ENST00000409890
• ENSP00000386304
• ENST00000410106
• ENSP00000387134
• ENST00000414593
• ENSP00000394774
• ENST00000444108
• ENSP00000401984
• ENST00000446464
• ENSP00000407599

Symbol

• RBED1
• RBM29
• LST3
• RBED1
• RBM29
• DFNB88

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
virus perturbation	0.76
tissue sample	0.7
cell type or tissue	0.67
transcription factor binding site profile	0.63

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Elmo Domain-containing Protein 3

DTO Classes

Protein / Signaling / Elmo Domain-containing Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.53   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 76   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.53   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0