Tbio CNRIP1 CB1 cannabinoid receptor-interacting protein 1

Protein Summary

Description

Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Isoform 2 does not have this effect. This gene encodes a protein that interacts with the C-terminal tail of cannabinoid receptor 1. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q96F85
• B2R4D0
• Q49AN4
• Q9UFZ0
• CRIP-1

Gene Name

• CNRIP1

Ensembl ID

• ENST00000263655
• ENSP00000263655
• ENSG00000119865
• ENST00000409559
• ENSP00000386883

Symbol

• C2orf32
• CRIP1
• C2orf32

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.62
tissue sample	0.59
histone modification site profile	0.55
kinase perturbation	0.54
cell type or tissue	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.92   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 81   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.92   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0