| Tbio | Protein dispatched homolog 1 |
Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity).
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| glioblastoma multiforme | 347 | 2.08847083413497E-24 |
| non-small cell lung carcinoma | 413 | 2.56565429826428E-23 |
| ovarian cancer | 8492 | 7.07057152668656E-17 |
| lung adenocarcinoma | 2714 | 1.01337483689024E-10 |
| posterior fossa group B ependymoma | 1530 | 1.33159053063474E-9 |
| pilocytic astrocytoma | 3086 | 1.01645063615328E-6 |
| lung carcinoma | 2844 | 1.51649609017509E-6 |
| atypical teratoid/rhabdoid tumor | 1095 | 5.75328760130323E-5 |
| intraductal papillary-mucinous adenoma (IPMA) | 2956 | 3.58240054750085E-4 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Chromosome 1q41-q42 deletion syndrome | 3 | 5.947 | 3.0 |
| Holoprosencephaly | 52 | 4.723 | 2.4 |
| Pelger-Huet anomaly | 8 | 3.638 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| posterior fossa group B ependymoma | 1.600 | 0.000 |
| glioblastoma multiforme | 1.100 | 0.000 |
| atypical teratoid/rhabdoid tumor | 2.100 | 0.000 |
| non-small cell lung carcinoma | -1.600 | 0.000 |
| intraductal papillary-mucinous adenoma (... | 1.500 | 0.000 |
| lung adenocarcinoma | -1.400 | 0.000 |
| pilocytic astrocytoma | 1.500 | 0.000 |
| lung carcinoma | -1.400 | 0.000 |
| ovarian cancer | -2.900 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Chicken | OMA Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| Fruitfly | OMA EggNOG |
| PMID | Text |
|---|---|
| 25824302 | The top single-nucleotide polymorphism (SNP) was rs17162912 (P=1.76 x 10(-8)), which is near the DISP1 gene on 1q41-q42, a microdeletion region implicated in neurological development. |
| 22733134 | DISP-1 is required for non-small cell lung carcinoma cells proliferation |
| 20951845 | Studies indicate that DISP1 haploinsufficiency may not be solely responsible for the major features of 1q41q42 microdeletion syndrome, and other genes in the SRO likely play a role in the phenotype. |
| 20799323 | report of 1st de novo DISP1 point mutation in patient with congenital diaphragmatic hernia (CDH); finding with Disp1 embryonic mouse diaphragm and lung expression and previously reported 1q41q42 aberrations in CDH suggests DISP1 may be CDH candidate gene |
| 20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 19184110 | describe two independent families with truncating mutations in DISP1 that resemble the cardinal craniofacial and neuro-developmental features of a recently described microdeletion syndrome that includes this gene |
MAMSNGNNDFVVLSNSSIATSAANPSPLTPCDGDHAAQQLTPKEATRTKVSPNGCLQLNGTVKSSFLPLD 1 - 70 NQRMPQMLPQCCHPCPYHHPLTSHSSHQECHPEAGPAAPSALASCCMQPHSEYSASLCPNHSPVYQTTCC 71 - 140 LQPSPSFCLHHPWPDHFQHQPVQQHIANIRPSRPFKLPKSYAALIADWPVVVLGMCTMFIVVCALVGVLV 141 - 210 PELPDFSDPLLGFEPRGTAIGQRLVTWNNMVKNTGYKATLANYPFKYADEQAKSHRDDRWSDDHYEREKR 211 - 280 EVDWNFHKDSFFCDVPSDRYSRVVFTSSGGETLWNLPAIKSMCNVDNSRIRSHPQFGDLCQRTTAASCCP 281 - 350 SWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLGPDCWDMAARRKDQLKCTNVPRKCTK 351 - 420 YNAVYQILHYLVDKDFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWNSSDGVTTITGIEFG 421 - 490 IKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEFFPFMNL 491 - 560 TALIILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAI 561 - 630 RCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNIFTCFKKPQQQIYDNKSCWTVACQKCHKVLFAISE 631 - 700 ASRIFFEKVLPCIVIKFRYLWLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKK 701 - 770 LFMFERVHHGEELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSSFNIASPASQAWILHFCQKLRNQTFF 771 - 840 YQTDEQDFTSCFIETFKQWMENQDCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTP 841 - 910 GPRFDINDTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSL 911 - 980 SDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSV 981 - 1050 DFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISW 1051 - 1120 AFATFFFQCMCRCLGPQGTCGQIPLPKKLQCSAFSHALSTSPSDKGQSKTHTINAYHLDPRGPKSELEHE 1121 - 1190 FYELEPLASHSCTAPEKTTYEETHICSEFFNSQAKNLGMPVHAAYNSELSKSTESDAGSALLQPPLEQHT 1191 - 1260 VCHFFSLNQRCSCPDAYKHLNYGPHSCQQMGDCLCHQCSPTTSSFVQIQNGVAPLKATHQAVEGFVHPIT 1261 - 1330 HIHHCPCLQGRVKPAGMQNSLPRNFFLHPVQHIQAQEKIGKTNVHSLQRSIEEHLPKMAEPSSFVCRSTG 1331 - 1400 SLLKTCCDPENKQRELCKNRDVSNLESSGGTENKAGGKVELSLSQTDASVNSEHFNQNEPKVLFNHLMGE 1401 - 1470 AGCRSCPNNSQSCGRIVRVKCNSVDCQMPNMEANVPAVLTHSELSGESLLIKTL 1471 - 1524 //
| PMID | Year | Title |
|---|---|---|
| 25824302 | 2016 | Whole-genome association analysis of treatment response in obsessive-compulsive disorder. |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 22733134 | 2013 | The hedgehog processing pathway is required for NSCLC growth and survival. |
| 20951845 | New cases and refinement of the critical region in the 1q41q42 microdeletion syndrome. | |
| 20799323 | 2010 | Characterization of the chromosome 1q41q42.12 region, and the candidate gene DISP1, in patients with CDH. |
| 20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | |
| 19184110 | 2009 | Truncating loss-of-function mutations of DISP1 contribute to holoprosencephaly-like microform features in humans. |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
| 16258256 | 2005 | Hedgehog signaling pathway and gastric cancer. |
| More... |
