| Tbio | Protein dispatched homolog 1 |
Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause a increase in SHH secretion (PubMed:22902404).
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Gastrointestinal Stromal Tumors | 48 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Alobar Holoprosencephaly | 14 |
| Lobar Holoprosencephaly | 20 |
| Semilobar Holoprosencephaly | 14 |
| Disease | Target Count | P-value |
|---|---|---|
| glioblastoma multiforme | 142 | 2.1e-24 |
| ovarian cancer | 8520 | 7.1e-17 |
| non-small cell lung cancer | 2890 | 7.3e-13 |
| lung adenocarcinoma | 2716 | 1.0e-10 |
| Astrocytoma, Pilocytic | 3081 | 1.3e-06 |
| lung carcinoma | 2843 | 1.5e-06 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 3.6e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.6e-03 |
| ependymoma | 4679 | 1.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Holoprosencephaly | 56 | 4.725 | 2.4 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Chromosome 1q41-q42 deletion syndrome | 4 | 5.899 | 2.9 |
| Pelger-Huet anomaly | 8 | 3.599 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| Astrocytoma, Pilocytic | 1.500 | 1.3e-06 |
| atypical teratoid / rhabdoid tumor | 2.000 | 1.6e-03 |
| ependymoma | 1.100 | 1.6e-02 |
| glioblastoma multiforme | 1.100 | 2.1e-24 |
| intraductal papillary-mucinous adenoma (... | 1.500 | 3.6e-04 |
| lung adenocarcinoma | -1.400 | 1.0e-10 |
| lung carcinoma | -1.400 | 1.5e-06 |
| non-small cell lung cancer | -1.067 | 7.3e-13 |
| ovarian cancer | -2.900 | 7.1e-17 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| OMA EggNOG |
MAMSNGNNDFVVLSNSSIATSAANPSPLTPCDGDHAAQQLTPKEATRTKVSPNGCLQLNGTVKSSFLPLD 1 - 70 NQRMPQMLPQCCHPCPYHHPLTSHSSHQECHPEAGPAAPSALASCCMQPHSEYSASLCPNHSPVYQTTCC 71 - 140 LQPSPSFCLHHPWPDHFQHQPVQQHIANIRPSRPFKLPKSYAALIADWPVVVLGMCTMFIVVCALVGVLV 141 - 210 PELPDFSDPLLGFEPRGTAIGQRLVTWNNMVKNTGYKATLANYPFKYADEQAKSHRDDRWSDDHYEREKR 211 - 280 EVDWNFHKDSFFCDVPSDRYSRVVFTSSGGETLWNLPAIKSMCNVDNSRIRSHPQFGDLCQRTTAASCCP 281 - 350 SWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLGPDCWDMAARRKDQLKCTNVPRKCTK 351 - 420 YNAVYQILHYLVDKDFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWNSSDGVTTITGIEFG 421 - 490 IKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEFFPFMNL 491 - 560 TALIILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAI 561 - 630 RCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNIFTCFKKPQQQIYDNKSCWTVACQKCHKVLFAISE 631 - 700 ASRIFFEKVLPCIVIKFRYLWLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKK 701 - 770 LFMFERVHHGEELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSSFNIASPASQAWILHFCQKLRNQTFF 771 - 840 YQTDEQDFTSCFIETFKQWMENQDCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTP 841 - 910 GPRFDINDTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSL 911 - 980 SDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSV 981 - 1050 DFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISW 1051 - 1120 AFATFFFQCMCRCLGPQGTCGQIPLPKKLQCSAFSHALSTSPSDKGQSKTHTINAYHLDPRGPKSELEHE 1121 - 1190 FYELEPLASHSCTAPEKTTYEETHICSEFFNSQAKNLGMPVHAAYNSELSKSTESDAGSALLQPPLEQHT 1191 - 1260 VCHFFSLNQRCSCPDAYKHLNYGPHSCQQMGDCLCHQCSPTTSSFVQIQNGVAPLKATHQAVEGFVHPIT 1261 - 1330 HIHHCPCLQGRVKPAGMQNSLPRNFFLHPVQHIQAQEKIGKTNVHSLQRSIEEHLPKMAEPSSFVCRSTG 1331 - 1400 SLLKTCCDPENKQRELCKNRDVSNLESSGGTENKAGGKVELSLSQTDASVNSEHFNQNEPKVLFNHLMGE 1401 - 1470 AGCRSCPNNSQSCGRIVRVKCNSVDCQMPNMEANVPAVLTHSELSGESLLIKTL 1471 - 1524 //
