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Tdark 39S ribosomal protein L53, mitochondrial

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 1p. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 9
PubMed Score 0.87
PubTator Score 0.37

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Disease Target Count Z-score Confidence
Cleft Lip 141 3.238 1.6
Cleft Palate 271 3.098 1.5

Expression

Synonym

Accession Q96EL3 L53mt
Symbols L53MT

Gene

MRPL53

  Ortholog (7)

Species Source Disease
OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA

 UniProt Keyword (8)

 GO Component (2)

 GO Process (2)

 Compartment GO Term (39)

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 HCA RNA Cell Line (56)

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Pathway (6)

Protein-protein Interaction (54)

S100P   MRPL12   MRPL46   MTIF2   MRPL45   MRPL9   MRPL32   MRPL11   DBT   MRPL48   MRPL40   MRPL3   MRPL1   MRPL39   MRPL23   MRPL41   MRPL22   MRPL37   MRPL28   MRPL10   MRPL24   MRPL49   MRPL44   MRPL50   MRPL38   MRPL20   PCBP4   MRPL27   MRPL55   MALSU1   MRPL47   MRPL16   FAM32A   MRPL4   MRPL19   MRPL58   MRPL2   MRPS18A   MRPL15   MRPL21   MRPL13   MRPL43   MRPL17   MRPL33   GADD45GIP1   MRPL35   MRPL42   MRPS30   MRPL18   MRPL30   MRPL14   MRPL51   MRPL57   MRPL34  

PDB (4)

Gene RIF (1)

AA Sequence 

MAAALARLGLRPVKQVRVQFCPFEKNVESTRTFLQTVSSEKVRSTNLNCSVIADVRHDGSEPCVDVLFGD      1 - 70
GHRLIMRGAHLTALEMLTAFASHIRARDAAGSGDKPGADTGR                                 71 - 112
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Text Mined References (12)

PMID Year Title