| Tdark | 39S ribosomal protein L53, mitochondrial |
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 1p. [provided by RefSeq, Jul 2008]
Comments
| PMID | Year | Title |
|---|---|---|
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| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 12706105 | 2003 | Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
| 11551941 | 2001 | The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. |
| 11329013 | 2001 | Creation of genome-wide protein expression libraries using random activation of gene expression. |
| 8889548 | 1996 | Normalization and subtraction: two approaches to facilitate gene discovery. |
