Tdark NEURL3 E3 ubiquitin-protein ligase NEURL3

Protein Summary

Description

E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation.

Uniprot Accession IDs

• Q96EH8

Gene Name

• NEURL3

Ensembl ID

• ENST00000451794
• ENSP00000478591
• ENSG00000163121

Symbol

• LINCR
• LINCR
• RNF132

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.64
histone modification site profile	0.56
transcription factor binding site profile	0.56
transcription factor perturbation	0.54
cell line	0.52

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Neurl3

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Neurl3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.85   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 25   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.85   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0