| Tbio | Elongator complex protein 4 |
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.
This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. This gene has also been associated with Rolandic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. This gene has also been associated with Rolandic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| tuberculosis | 2010 | 5.1e-06 |
| ovarian cancer | 8520 | 4.0e-04 |
| psoriasis | 6694 | 1.2e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Benign epilepsy with centrotemporal spikes | 13 | 6.072 | 3.0 |
| Landau-Kleffner syndrome | 4 | 3.565 | 1.8 |
| Developmental coordination disorder | 8 | 3.371 | 1.7 |
| WAGR syndrome | 10 | 3.161 | 1.6 |
| Disease | Target Count |
|---|---|
| Aniridia 1 | 5 |
| Disease | log2 FC | p |
|---|---|---|
| ovarian cancer | 1.400 | 4.0e-04 |
| psoriasis | 1.300 | 1.2e-03 |
| tuberculosis | 1.300 | 5.1e-06 |
MAAVATCGSVAASTGSAVATASKSNVTSFQRRGPRASVTNDSGPRLVSIAGTRPSVRNGQLLVSTGLPAL 1 - 70 DQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKEDPANILQELPAPLLDDKCKK 71 - 140 EFDEDVYNHKTPESNIKMKIAWRYQLLPKMEIGPVSSSRFGHYYDASKRMPQELIEASNWHGFFLPEKIS 141 - 210 STLKVEPCSLTPGYTKLLQFIQNIIYEEGFDGSNPQKKQRNILRIGIQNLGSPLWGDDICCAENGGNSHS 211 - 280 LTKFLYVLRGLLRTSLSACIITMPTHLIQNKAIIARVTTLSDVVVGLESFIGSERETNPLYKDYHGLIHI 281 - 350 RQIPRLNNLICDESDVKDLAFKLKRKLFTIERLHLPPDLSDTVSRSSKMDLAESAKRLGPGCGMMAGGKK 351 - 420 HLDF 421 - 424 //
