| Tdark | RING finger and SPRY domain-containing protein 1 |
This gene encodes a glycoprotein that contains a RING-type zinc finger domain and an SPRY domain of unknown function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| juvenile dermatomyositis | 1187 | 5.4e-12 |
| ovarian cancer | 8520 | 1.3e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.2e-04 |
| glioblastoma | 5792 | 2.9e-04 |
| primitive neuroectodermal tumor | 3035 | 3.6e-04 |
| Astrocytoma, Pilocytic | 3081 | 6.1e-04 |
| astrocytic glioma | 2597 | 1.0e-03 |
| oligodendroglioma | 2850 | 1.2e-03 |
| group 4 medulloblastoma | 1855 | 1.2e-03 |
| adrenocortical carcinoma | 1428 | 2.4e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Intellectual disability | 1016 | 0.0 | 4.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Spondyloepimetaphyseal dysplasia | 12 | 3.789 | 1.9 |
| Disease | Target Count |
|---|---|
| SPONDYLOEPIMETAPHYSEAL DYSPLASIA, FADEN-ALKURAYA TYPE | 1 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | 1.075 | 2.4e-03 |
| astrocytic glioma | 1.200 | 1.0e-03 |
| Astrocytoma, Pilocytic | 1.100 | 6.1e-04 |
| atypical teratoid / rhabdoid tumor | 1.400 | 2.2e-04 |
| glioblastoma | 1.100 | 2.9e-04 |
| group 4 medulloblastoma | 1.400 | 1.2e-03 |
| juvenile dermatomyositis | 1.065 | 5.4e-12 |
| oligodendroglioma | 1.300 | 1.2e-03 |
| ovarian cancer | -1.100 | 1.3e-04 |
| primitive neuroectodermal tumor | 1.100 | 3.6e-04 |
MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQQQAENSAVPT 1 - 70 ADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDNDQEPPYSMITLHEMAETDEGWLD 71 - 140 VVQSLIRVIPLEDPLGPAVITLLLDECPLPTKDALQKLTEILNLNGEVACQDSSHPAKHRNTSAVLGCLA 141 - 210 EKLAGPASIGLLSPGILEYLLQCLKLQSHPTVMLFALIALEKFAQTSENKLTISESSISDRLVTLESWAN 211 - 280 DPDYLKRQVGFCAQWSLDNLFLKEGRQLTYEKVNLSSIRAMLNSNDVSEYLKISPHGLEARCDASSFESV 281 - 350 RCTFCVDAGVWYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGDDEYSCAYDGCRQLIWYNARSKPHIHP 351 - 420 CWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQVFSSTVSGFFAAASFMSYQQCEFNFGAKPFKYPPSMK 421 - 490 FSTFNDYAFLTAEEKIILPRHRRLALLKQVSIRENCCSLCCDEVADTQLKPCGHSDLCMDCALQLETCPL 491 - 560 CRKEIVSRIRQISHIS 561 - 576 //
