Tdark | RING finger and SPRY domain-containing protein 1 |
This gene encodes a glycoprotein that contains a RING-type zinc finger domain and an SPRY domain of unknown function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Comments
Disease | Target Count | P-value |
---|---|---|
juvenile dermatomyositis | 1189 | 5.446801460216E-12 |
atypical teratoid / rhabdoid tumor | 4369 | 2.15148770606721E-4 |
glioblastoma | 5572 | 2.920761393271E-4 |
primitive neuroectodermal tumor | 3031 | 3.5551339578129E-4 |
pilocytic astrocytoma | 3086 | 4.47567923954347E-4 |
ovarian cancer | 8492 | 9.19423445277633E-4 |
astrocytic glioma | 2241 | 0.00101578120611274 |
oligodendroglioma | 2849 | 0.00117237901132977 |
group 4 medulloblastoma | 1875 | 0.00120275879142449 |
adrenocortical carcinoma | 1427 | 0.00243967578718277 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Intellectual disability | 573 | 0.0 | 4.0 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Spondyloepimetaphyseal dysplasia | 9 | 3.789 | 1.9 |
Disease | Target Count |
---|---|
Spondyloepimetaphyseal dysplasia, Faden-Alkuraya type | 1 |
Disease | log2 FC | p |
---|---|---|
astrocytic glioma | 1.200 | 0.001 |
oligodendroglioma | 1.300 | 0.001 |
glioblastoma | 1.100 | 0.000 |
group 4 medulloblastoma | 1.400 | 0.001 |
atypical teratoid / rhabdoid tumor | 1.400 | 0.000 |
primitive neuroectodermal tumor | 1.100 | 0.000 |
juvenile dermatomyositis | 1.065 | 0.000 |
adrenocortical carcinoma | 1.075 | 0.002 |
pilocytic astrocytoma | 1.100 | 0.000 |
ovarian cancer | 1.400 | 0.001 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA Inparanoid |
Dog | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Opossum | EggNOG Inparanoid |
Platypus | OMA EggNOG Inparanoid |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
C. elegans | OMA EggNOG |
PMID | Text |
---|---|
26365341 | RSPRY1 Mutations are associated with Progressive Skeletal Dysplasia. |
MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQQQAENSAVPT 1 - 70 ADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDNDQEPPYSMITLHEMAETDEGWLD 71 - 140 VVQSLIRVIPLEDPLGPAVITLLLDECPLPTKDALQKLTEILNLNGEVACQDSSHPAKHRNTSAVLGCLA 141 - 210 EKLAGPASIGLLSPGILEYLLQCLKLQSHPTVMLFALIALEKFAQTSENKLTISESSISDRLVTLESWAN 211 - 280 DPDYLKRQVGFCAQWSLDNLFLKEGRQLTYEKVNLSSIRAMLNSNDVSEYLKISPHGLEARCDASSFESV 281 - 350 RCTFCVDAGVWYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGDDEYSCAYDGCRQLIWYNARSKPHIHP 351 - 420 CWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQVFSSTVSGFFAAASFMSYQQCEFNFGAKPFKYPPSMK 421 - 490 FSTFNDYAFLTAEEKIILPRHRRLALLKQVSIRENCCSLCCDEVADTQLKPCGHSDLCMDCALQLETCPL 491 - 560 CRKEIVSRIRQISHIS 561 - 576 //
PMID | Year | Title |
---|---|---|
26365341 | 2015 | Identification of a Recognizable Progressive Skeletal Dysplasia Caused by RSPRY1 Mutations. |
24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
12975309 | 2003 | The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
11853319 | 2001 | Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. |