Tbio RMC1 Regulator of MON1-CCZ1 complex

Protein Summary

Description

Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization (PubMed:29038162). This gene encodes a colon cancer associated protein. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• Q96DM3
• Q9BU17
• Q9Y5M0

Gene Name

• RMC1

Ensembl ID

• ENST00000269221
• ENSP00000269221
• ENSG00000141452

Symbol

• C18orf8
• MIC1
• WDR98
• MIC1
• Mic-1
• WDR98
• C18orf8
• HsT2591

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.79   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.79   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0