Property Summary

NCBI Gene PubMed Count 34
PubMed Score 40.74
PubTator Score 36.49

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
lung carcinoma 2844 6.73242735178649E-30
glioblastoma multiforme 347 7.23248789052065E-21
non-small cell lung cancer 2798 9.40064912001597E-16
lung adenocarcinoma 2714 8.68900834099315E-10
acute quadriplegic myopathy 1157 1.23207592019051E-7
Pick disease 1893 8.46927412396922E-7
ovarian cancer 8492 1.8664378242238E-6
Breast cancer 3099 2.01975792686615E-6
cystic fibrosis 1670 3.89360903303985E-6
interstitial cystitis 2299 1.18412365602024E-5
pituitary cancer 1972 1.2669611737102E-5
chronic lymphosyte leukemia 232 2.28873277699623E-5
osteosarcoma 7933 2.6043422784276E-5
Amyotrophic Lateral Sclerosis 432 3.90373381909674E-5
medulloblastoma, large-cell 6234 1.47585137292935E-4
primitive neuroectodermal tumor 3031 2.02882081553625E-4
adrenocortical carcinoma 1427 2.39232985636323E-4
atypical teratoid / rhabdoid tumor 4369 2.5498915740971E-4
hepatocellular carcinoma 550 0.00248091273230634
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00251335727294928
invasive ductal carcinoma 2950 0.00266842186989855
pancreatic cancer 2300 0.00599813286590305
primary pancreatic ductal adenocarcinoma 1271 0.006273387280431
ductal carcinoma in situ 1745 0.00784486641221624
oligodendroglioma 2849 0.00925696714756259
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0102072252772389
astrocytic glioma 2241 0.0108195268735574
X-linked recessive Emery-Dreifuss muscular dystrophy 18 0.017384037673362
active ulcerative colitis 477 0.0185626846356696
Alzheimer's disease 644 0.0185865787017585
ependymoma 2514 0.027465572825931
group 3 medulloblastoma 2254 0.0284859035479257
subependymal giant cell astrocytoma 2287 0.0399213354174534
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.041814919271038
Disease Target Count Z-score Confidence
Cancer 2346 3.029 1.5



Accession Q96DH6 Q7Z6M7 Q8N9T4 Musashi-2
Symbols MSI2H


  Ortholog (6)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Horse OMA Inparanoid
Anole lizard OMA Inparanoid

Gene RIF (24)

27121842 MSI2 directly attenuates aryl hydrocarbon receptor (AHR) signalling through post-transcriptional downregulation of canonical AHR pathway components in cord blood haematopoietic stem and progenitor cells
26673327 Concomitant loss of function of both MSI1 is sufficient to abrogate the growth of human colorectal cancer cells, and Msi gene deletion inhibits tumorigenesis in several mouse models of intestinal cancer.
25851660 This review highlights both the essential contribution of RBPs to posttranscriptional regulation and the importance of the Musashi family as master regulators of male gamete development--{REVIEW}
25774828 the MSI2 RNA-binding protein has a role in transformation of intestinal epithelium
25664853 MSI2 controls efficient translation of the oncogenic leukemic stem cell self-renewal program.
25449073 Acute myeloid leukemia patients have a higher level of MSI2 gene expression.
25380226 Msi proteins contribute to an epithelial gene expression program in neural and mammary cell types.
25363400 Up-regulated MSI2 is associated with more aggressive chronic myeloid leukemia.
25090928 These results confirm the association of MSI2 expression with outcome in adult B-ALL and demonstrate the utility of MSI2 as a clinical prognostic biomarker.
24305552 MSI2 correlates with epithelial-mesenchymal transition and has the potential to be a new predictive biomarker of hepatocellular carcinoma prognosis and invasion.

AA Sequence


Text Mined References (40)

PMID Year Title
27121842 2016 Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells.
26673327 2015 The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins.
25851660 RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family.
25774828 2015 Transformation of the intestinal epithelium by the MSI2 RNA-binding protein.
25664853 2015 Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.
25449073 2014 [Expression of Musashi2 gene in de novo acute myeloid leukemia and its clinical implications].
25416956 2014 A proteome-scale map of the human interactome network.
25380226 2014 Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state.
25363400 2015 Up-regulated MSI2 is associated with more aggressive chronic myeloid leukemia.
25090928 2015 Prognostic significance of MSI2 predicts unfavorable outcome in adult B-acute lymphoblastic leukemia.