Property Summary

NCBI Gene PubMed Count 25
Grant Count 33
R01 Count 24
Funding $3,468,975.41
PubMed Score 160.59
PubTator Score 45.06

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (10)

Disease log2 FC p
malignant mesothelioma -1.200 0.000
ependymoma -1.400 0.039
glioblastoma -1.800 0.000
osteosarcoma 1.471 0.000
medulloblastoma -2.200 0.000
atypical teratoid / rhabdoid tumor -2.000 0.000
medulloblastoma, large-cell -2.800 0.000
primitive neuroectodermal tumor -1.500 0.001
pediatric high grade glioma -1.700 0.000
pilocytic astrocytoma -1.300 0.000

Gene RIF (10)

PMID Text
23024001 High HDAC11 expression is associated with neoplasms.
21806350 Data indicate a pronounced deregulation of HDAC genes HDAC9 and HDAC11 in patients with Philadelphia-negative chronic myeloproliferative neoplasms: essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF).
21239696 These results demonstrate for the first time that HDAC11 plays an essential role in regulating OX40L expression.
20980834 HDAC11 associates with replication origins inhibits Cdt1-induced re-replication and suppresses MCM loading.
20467334 We found a reduction of HDAC 11 mRNA and increased HDAC 2 levels in amyotrophic lateral sclerosis brain and spinal cord compared with controls.
19276081 Cdt1 undergoes acetylation and is reversibly deacetylated by HDAC11
19011628 HDAC11 negatively regulated expression of the gene encoding interleukin 10 in antigen-presenting cells.
17201809 the absence of tumour-specific somatic events in WNT7A and HDAC11 suggests that these genes are unlikely to have a classical tumour suppressor gene role in sporadic malignant pancreatic endocrine tumours
16142391 Fluorescence in situ hybridization analysis localized HDAC11 gene to chromosome 3p25, a region characterized by frequent gains and losses of chromosomal material in a number of various types of cancer.
11948178 cloning and functional characterization

AA Sequence

MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEED      1 - 70
LLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGG     71 - 140
FHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYP    141 - 210
GDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVK    211 - 280
RDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP       281 - 347
//

Text Mined References (27)

PMID Year Title
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23024001 2013 HDAC11 is a novel drug target in carcinomas.
21806350 2012 Increased gene expression of histone deacetylases in patients with Philadelphia-negative chronic myeloproliferative neoplasms.
21239696 2011 HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma.
20980834 2010 Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin.
20881960 2010 Hundreds of variants clustered in genomic loci and biological pathways affect human height.
20467334 2010 Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis.
19276081 2009 Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1.
19088734 2009 From immunity to tolerance through HDAC.
19011628 2009 The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance.
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