Protein Summary
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
- ENST00000295757
- ENSP00000295757
- ENSG00000163517
- ENST00000522202
- ENSP00000429794
- HD11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.84 | ||
cellular component | 0.74 | ||
molecular function | 0.7 | ||
small molecule perturbation | 0.69 | ||
transcription factor binding site profile | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 382.25 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 405 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 382.25 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 405 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 185
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 5