Property Summary

NCBI Gene PubMed Count 29
PubMed Score 222.79
PubTator Score 22.38

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
osteosarcoma 7933 8.12815691015763E-9
pancreatic cancer 2300 9.70756170452724E-8
intraductal papillary-mucinous adenoma (IPMA) 2956 4.23858275717862E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 4.54974542345685E-4
breast carcinoma 1614 6.70750970273282E-4
interstitial cystitis 2299 0.00116695222113817
Atopic dermatitis 944 0.00155210708569797
psoriasis 6685 0.0019529425292718
chronic rhinosinusitis 512 0.00262819423439937
fibroadenoma 557 0.00430355284034603
active ulcerative colitis 477 0.00461602809333549
invasive ductal carcinoma 2950 0.00538774017440412
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00763747396117561
cystic fibrosis 1670 0.0111587648771679
pancreatic ductal adenocarcinoma liver metastasis 1795 0.022507050952297
lung cancer 4473 0.022848119086034
active Crohn's disease 918 0.0298406324934241
adrenocortical carcinoma 1427 0.0351138862534996
ductal carcinoma in situ 1745 0.0388196569069542

Expression

Synonym

Accession Q96DA0 A6NIY1 B2R4F6 Q6UW28
Symbols EECP
PAUF
JCLN2
HRPE773
PRO1567

Gene

PDB

3AQG  

  Ortholog (3)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Dog OMA EggNOG

Gene RIF (14)

PMID Text
26336989 PAUF mediated dendritic cell activation and immune stimulation are dependent on TLR4
25727013 constitutive suppression of PAUF sensitized Bxpc3 pancreatic cancer cells to oncolytic parvovirus H-1 infection
25079514 PAUF rs12373A>C polymorphisms are associated with colorectal cancer.
23677445 PAUF-siRNA inhibited the proliferation of colorectal cancer cells, promoted their apoptosis and induced G0/G1 cell cycle arrest. At the same time, PAUF-siRNA inhibited the invasion, adhesion and migration of the tumor cells.
22907431 new possibilities for PAUF's role in the pathogenesis of angiogenesis-dependent diseases
22640743 activation of SIRT1 inhibited the proliferation of pancreatic cancer -PAUF cells by down-regulation of cyclin-D1, a target molecule of beta-catenin.
21464589 PAUF-mediated FAK activation plays an important role in pancreatic cancer progression.
21196815 PAUF can up-regulate and stabilize beta-catenin via a novel pattern of phosphorylation, thereby contributing to the rapid proliferation of pancreatic cancer cells.
21110947 the sugar-binding site and the adjacent basic patch of ZG16p and ZG16b cooperatively form a functional glycosaminoglycan-binding site.
20858015 Data demonstrate that the host salivary protein CSP-1 (HRPE773 GenBank AAQ89380.1) binds to S. mutans cells and may influence the initial colonization of this pathogenic bacterium onto the tooth surface.
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AA Sequence

MGAQGAQESIKAMWRVPGTTRRPVTGESPGMHRPEAMLLLLTLALLGGPTWAGKMYGPGGGKYFSTTEDY      1 - 70
DHEITGLRVSVGLLLVKSVQVKLGDSWDVKLGALGGNTQEVTLQPGEYITKVFVAFQAFLRGMVMYTSKD     71 - 140
RYFYFGKLDGQISSAYPSQEGQVLVGIYGQYQLLGIKSIGFEWNYPLEEPTTEPPVNLTYSANSPVGR      141 - 208
//

Text Mined References (31)

PMID Year Title
26336989 2015 Pancreatic adenocarcinoma upregulated factor serves as adjuvant by activating dendritic cells through stimulation of TLR4.
25727013 2015 Pancreatic adenocarcinoma upregulated factor (PAUF) confers resistance to pancreatic cancer cells against oncolytic parvovirus H-1 infection through IFNA receptor-mediated signaling.
25079514 2015 Genetic variation in microRNA-binding site and prognosis of patients with colorectal cancer.
23677445 2013 Silencing of pancreatic adenocarcinoma upregulated factor by RNA interference inhibits the malignant phenotypes of human colorectal cancer cells.
23580065 2013 Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
22907431 2013 Pancreatic adenocarcinoma upregulated factor, a novel endothelial activator, promotes angiogenesis and vascular permeability.
22664934 2012 Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
22640743 2012 SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of ?-catenin.
More...